Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
By generating Cd14−/− and Casp11−/− mice strains on a Tlr4−/− background, we dissociate CD14's known role in TLR4 signaling from its role in caspase -11 activation and show a TLR4 …
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo …
CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4
CD14 first captures and transports LPS to the plasma membrane localized complex of TLR4 and MD2, which signals through the TIRAP-MyD88 adaptors to activate inflammatory cytokine …
A TLR4-independent critical role for CD14 in intracellular ... - Cell …
2022年5月3日 · By generating Cd14 −/− mice on a Tlr4-deficient background, we reveal that CD14 plays an essential TLR4-independent role in caspase-11 activation in vivo by delivering …
CD14 is critical for TLR2-mediated M1 macrophage activation
2017年8月1日 · Because co-receptors influence agonist binding to TLRs, we investigated whether CD14 is required for macrophage activation induced by ArtinM.
Targeting the TLR Co-Receptor CD14 with TLR2-Derived Peptides …
2013年5月15日 · We assessed the potential of the TLR co-receptor CD14 as a target for therapeutics by investigating the magnitude of its influence on TLR responses. We studied the …
Multifaceted role of CD14 in innate immunity and tissue …
2023年12月1日 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage …
A TLR4-independent critical role for CD14 in intracellular LPS
2022年5月3日 · Mechanistically, CD14 enables caspase-11 activation by mediating cytosolic localization of LPS in a TLR4-independent manner. Overall, our findings attribute a critical role …
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
2011年11月11日 · CD14 first captures and transports LPS to the plasma membrane localized complex of TLR4 and MD2, which signals through the TIRAP-MyD88 adaptors to activate …
CD14 is a coreceptor of Toll-like receptors 7 and 9 - PMC
In this study, we show that CD14 (cluster of differentiation 14) constitutively interacts with the MyD88-dependent TLR7 and TLR9. CD14 was necessary for TLR7- and TLR9-dependent …