
Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope …
In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine …
Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
CD14 是一种糖磷脂酰肌醇锚定的质膜蛋白,在 LPS 介导的 TLR4 激活中具有长期确定的作用;CD14 与 LPS 结合并将 LPS 转移到 TLR4-MD2 复合物,从而启动 myddosome 组装和信号 …
The CD14+/lowCD16+ monocyte subset is more susceptible to
2010年11月4日 · The apoptosis of CD14 +/low CD16 + monocytes was ROS dependent as reducing ROS levels significantly reduced cell death. This is the first report of a differential …
Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope …
2020年11月20日 · In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS …
Single-cell analysis of CD14+CD16+ monocytes identifies a …
Having identified subpopulations of CD14 + CD16 + monocytes with increased expression of genes associated with heightened inflammation and pathogenicity, and decreased levels of …
Impact of CD14 on Reactive Oxygen Species Production from …
2019年3月3日 · Obtained results suggest that glycosylphosphatidylinositol-anchored CD14 is the key player in LPS-induced PMN priming for fMLP-triggered ROS production. We believe that …
Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope …
In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine …
Moreover, the consequences of antigenic recognition of CD14, TLR4, or CD11b by specific F(ab′) 2 fragments are not always investigated. In this review, we will discuss known …
Pro-inflammatory hepatic macrophages generate ROS through …
2017年12月21日 · These data suggested that endocytosis of TLR4–MD2 complex in human CD68 low CD14 high macrophages by palmitate-mediated ROS generation, which might be …
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo …