Cell Reports丨CD14在细胞内LPS传感中的独立于TLR4的关键作用
CD14 是一种糖磷脂酰肌醇锚定的质膜蛋白，在 LPS 介导的 TLR4 激活中具有长期确定的作用；CD14 与 LPS 结合并将 LPS 转移到 TLR4-MD2 复合物，从而启动 myddosome 组装和信号 …
CD14—细菌脂多糖的膜受体 - 知乎 - 知乎专栏
CD14 (cluster of differentiation 14)原称MY23抗原，是一种表面抗原，属细胞表面糖蛋白家族成员之一。 CD14基因编码的蛋白，优先表达于单核/巨噬细胞。 CD14是革兰阴性菌内毒素脂多糖 …
Computationally Designed Bispecific MD2/CD14 Binding Peptides …
2018年12月1日 · We used computational design methods to predict and optimize a total of 53 cyclic and linear peptides targeting myeloid differentiation 2 (MD2) and cluster of differentiation …
TLR4/CD14/MD2 Revealed as the Limited Toll-like Receptor
2022年12月15日 · We identified CD14 associated with unique characteristics of different serovars as the crucial factor of the TLR4/CD14/MD2 complex for Ct-mediated activation of the NF-κB …
Co-expression of MD2 and CD14 genes (human or mouse)
pDUO2-MD2/CD14 is an expression vector designed to co-express MD2 and CD14 genes known to interact with each other : human MD2 (480 bp) and human CD14 (1125 bp) or mouse MD2 …
Reconstruction of LPS Transfer Cascade Reveals Structural ... - PubMed
2017年1月17日 · LPS transfer to TLR4-MD2 is catalyzed by both LPS binding protein (LBP) and CD14. To define the sequential molecular interactions underlying this transfer, we …
CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4
CD14 first captures and transports LPS to the plasma membrane localized complex of TLR4 and MD2, which signals through the TIRAP-MyD88 adaptors to activate inflammatory cytokine …
Recent progress in the discovery of myeloid differentiation 2 (MD2 …
2018年6月1日 · Lipopolysaccharide (LPS) from the membrane of Gram-negative bacteria is recognized and extracted by LBP. CD14 then delivers LPS to the TLR4–MD2 complex. …
Modulation of the lipopolysaccharide receptor complex (CD14
The lipopolysaccharide (LPS) receptor complex consists of two interacting receptors (CD14 and TLR4) and an associated protein (MD-2). When engaged by LPS, as in gram-negative …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · The three-dimensional structural pattern diagram of LBP, CD14, TLR4, MD-2, and TLR4-MD-2 complex and the binding pattern diagram of LPS and TLR4-MD2 complex. A …