2024年8月28日 · Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder caused by the accumulation of cerebral amyloid-β (Aβ) in the tunica media and adventitia of leptomeningeal and cortical vessels of the brain. The resultant vascular fragility tends to manifest in normotensive elderly patients as lobar intracerebral hemorrhage.

2024年12月1日 · Overall, MRI is the modality of choice in assessing patients with suspected inflammatory cerebral amyloid angiopathy as it is able to visualize the characteristic microhemorrhages and cortical superficial siderosis of cerebral amyloid angiopathy.

2024年8月1日 · The Boston criteria 2.0 were proposed in 2022 in order to better include leptomeningeal and white matter characteristics into the diagnoses of probable and possible cerebral amyloid angiopathy (CAA) 1.

Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare but increasingly recognized subtype of CAA. CAA-RI consists of two subtypes: inflammatory cerebral amyloid angiopathy and amyloid β (Aβ)-related angiitis. Acute or subacute onset of cognitive decline or behavioral changes is the most common symptom of CAA-RI.

The identification at initial MRI of diffuse cortical and subcortical microhemorrhages in a distribution typical of CAA in elderly patients presenting with infiltrative white matter process or prominent leptomeningeal enhancement is highly suggestive of vascular inflammatory CAA.

2023年6月5日 · Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterized by the accumulation of amyloid beta-peptide within the leptomeninges and small/medium-sized cerebral blood vessels. The amyloid deposition results in fragile vessels that may manifest in lobar intracerebral hemorrhages (ICH).

2024年11月17日 · CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.0 became the new diagnostic standard for CAA, following the Modified Boston Criteria of 2010. The diagnostic criteria are a composite of clinical, imaging and histopathological findings.

2006年9月1日 · Cerebral amyloid angiopathy (CAA) is an important but underrecognized cause of cerebrovascular disorders that predominantly affect elderly patients. CAA results from deposition of β-amyloid protein in cortical, subcortical, and leptomeningeal vessels.

The MRI features of CAA-ri include bilateral and asymmetrical cortical and subcortical white matter vasogenic edema, associated with diffuse CMBs and/or CSS, mainly involving the temporal and parietal lobes, with a great prevalence of micro-hemorrhages in the area of cerebral vasogenic edema.

Radiologic findings at diagnosis were available in 27 patients with CAA without inflammation, 22 with ABRA, and 5 with CAA-RI. On MRI, leptomeningeal disease alone or with infiltrative white matter was significantly more frequent at presentation in patients with ABRA or CAA-RI compared with those with CAA (29.6% vs. 3.7%, P = 0.02; and 40.7% vs ...