2023年4月14日 · The concept of "BRCAness" was first described in 2004 to define the situation in which a homologous recombination repair (HRR) defect in a tumor relates to and phenocopies BRCA1 or BRCA2 loss-of-function mutations.

2016年1月18日 · BRCAness can be defined as a defect in double-strand break repair (DSBR) by homologous recombination repair (HRR). This process consists of a series of sequential steps, which involve several...

PARP抑制剂是一种靶向聚ADP核糖聚合酶 (Poly ADP-ribose Polymerase) 的癌症疗法。 它是第一种成功利用合成致死 (Synthetic Lethality) 概念获得批准在临床使用的抗癌药物。 它的原理不难理解：携带BRCA1或BRCA2种系基因突变 (germline...

The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genom …

2019年7月27日 · The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss. In turn, BRCA-deficient cells utilize error-prone DNA-repair pathways, causing increased genomic instability, which may be responsible for their sensitivity to DNA damaging agents and poly-(ADP)-ribose polymerase inhibitors (PARPis).

Here we review the concept of BRCAness, the phenotypes that some sporadic tumours share with familial-BRCA cancers. These properties in part reflect the underlying distinctive DNA-repair defect...

BRCAness refers to the damaged homologous recombination (HR) function due to the defects in HR-involved non-BRCA1/2 genes. BRCAness is the important marker for the use of synthetic lethal-based PARP inhibitor therapy in breast and ovarian cancer ...

2020年12月3日 · BRCAness is defined as a phenotypic copy of germline BRCA mutations, which describes presence of homologous recombination defects in sporadic cancers. We detected BRCAness by multiplex...

Over the past 20 years, there has been considerable progress in our understanding of the biological functions of the BRCA1 and BRCA2 cancer susceptibility genes. This has led to the development of new therapeutic approaches that target tumours with loss-of-function mutations in either BRCA1 or BRCA2.

2019年9月1日 · The concept of ‘BRCAness’ defines the pathogenesis and vulnerability of multiple cancers. The canonical definition of BRCAness is a defect in homologous recombination repair, mimicking BRCA1 or BRCA2 loss.