2025年3月30日 · BNIP3L (BCL2 Interacting Protein 3 Like) is a Protein Coding gene. Diseases associated with BNIP3L include Pediculus Humanus Capitis Infestation and Mitochondrial Dna Depletion Syndrome 13. Among its related pathways are Gene expression (Transcription) and TP53 Regulates Transcription of Cell Death Genes.

BNIP3L首先被发现为一种促凋亡的BCL2家族蛋白，可诱导细胞凋亡或坏死；不过最近的研究发现，BNIP3L可通过自噬促进网织红细胞的线粒体消除。 BNIP3与BNIP3L/NIX具有60%的同源性，基本结构和功能相似；在缺氧条件下BNIP3L/NIX和BNIP3会被转录激活，通常以同源二聚体的形式锚定在线粒体外膜，促发线粒体自噬。 使用Cobalt Chloride模拟低氧也可以达到此作用（图6）。 作为免疫学和细胞生物学一站式解决方案供应商，Proteintech可提供一系列线粒体自噬相关的抗 …

2021年12月20日 · BNIP3L promotes mitophagy either via recruiting autophagosomes to target mitochondria or enhancing the formation of autophagosomes. BNIP3L-mediated mitophagy is regulated at the...

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.

2009年2月20日 · BNIP3 (BCL2 and adenovirus E1B 19-kDa-interacting protein 3) and BNIP3-like (BNIP3L), also known as NIX, are proteins with homology to BCL2 in the BH3 domain, which induce both cell death and ...

该基因编码的蛋白质属于 Bcl-2 蛋白质家族中的促凋亡亚家族。 编码的蛋白质与 Bcl-2 结合并具有 BH3 结构域。 该蛋白直接靶向线粒体并引起细胞凋亡变化，包括膜电位的丧失和细胞色素 c 的释放。 [RefSeq 提供，2015 年 2 月] This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 Family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain.

2021年12月20日 · BNIP3L is initially known to clear the mitochondria during the development of reticulocytes. Recent studies indicated it also engages in a variety of physiological and pathological processes. In this review, we provide an overview of how BNIP3L induces mitophagy and discuss the biological functions of BNIP3L and its regulation at the molecular ...

2022年4月11日 · Autophagy-mediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency, but the molecular mechanisms that link autophagy-mediated mitochondrial...

2020年8月20日 · We determined that BNIP3L/NIX, a mitophagy receptor, was degraded by proteasomes, which led to mitophagy deficiency in both ischemic neurons and brains. BNIP3L exists as a monomer and homodimer in mammalian cells, but the effects of homodimer and monomer on mitophagy are unclear.

The most studied mitophagy receptor BCL2/adenovirus E1B 19-kDa-interacting protein 3-like (BNIP3L/NIX) is shown to be important for the programmed removal of healthy mitochondria during terminal differentiation of erythrocytes, but its role has been proven in various cell types.