Temporal re-enforcement of Stat5 activity in TEX cells strongly synergized with PD-1 blockade at expanding TEXint cells and partially reprogrammed the epigenetic landscape of TEX cells to rewire these cells towards more durably protective states with superior anti-tumor potential (Fig. 3) (Beltra et al., Immunity 2023).7 This work was proof of ...

Daniel Beltrá captures the profound beauty and vulnerability of the natural world in his photographs of natural landscapes and wildlife. Primarily a landscape photographer, Beltrá combines painterly abstraction with the haunting details of an earthly paradise in peril.

2024年2月27日 · Prof. Dr. Beltra Jean-Christophe is an immunologist who studies the fundamental mechanisms regulating adaptive T-cell responses to pathogens and cancer. Notably, he seeks to better understand the immunological processes limiting current anti-cancer immunotherapies and to develop innovative strategies to better complement these approaches ...

As a Parker Bridge Fellow, Dr. Beltra is currently developing a program to exploit TEX subsets biology to identify and characterize relevant pathways for the therapeutic manipulation of TEX cells, with a particular focus on cytokine-derived signals and transcriptional circuitries with the potential of complementing PD-1-based therapy and/or ...

2020年5月19日 · Here, we defined a four-cell-stage developmental framework for Tex cells. Two TCF1 + progenitor subsets were identified, one tissue restricted and quiescent and one more blood accessible, that gradually lost TCF1 as it divided and …

Using original murine models, I demonstrated a new role for the gamma-chain cytokines IL-2 and IL-15 in the development of CD8 T cell exhaustion (Beltra et al. PNAS 2016). This innovative work was among the first demonstrating the influence of cytokines in the process of CD8 T cell exhaustion paving the way to what represents now an intense ...

Reversing CD8+ T cell exhaustion is a major challenge of cancer immunotherapy. Yet, the epigenetic stability of the exhaustion program remains a key hinderance. Beltra et al. identify the transcription factor Stat5 as a key axis to exploit for rewiring exhausted CD8+ T cells toward more durably protective states.

2023年12月12日 · We examined epigenetic transitions between Tex cell subsets and revealed a reciprocally antagonistic circuit between Stat5a and Tox. Stat5 directed Tex int cell formation and re-instigated partial effector biology during this Tex prog -to-Tex int cell transition.

2023年12月12日 · We examined epigenetic transitions between Tex cell subsets and revealed a reciprocally antagonistic circuit between Stat5a and Tox. Stat5 directed Tex int cell formation and re-instigated partial effector biology during this Texprog -to-Tex int cell transition.

D Costamagna, V Casters, M Beltrà, M Sampaolesi, A Van Campenhout, ... Cells 11 (21), 3351, 2022. 6: 2022: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging. D Sebastián, M Beltrà, A Irazoki, D …