Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family members can either inhibit or induce it. [6][7] It was the …

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). BCL-2 and its closest homolog promote cell survival …

The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. [2]

2 days ago · BCL-2 did not promote cell proliferation but inhibited cell death, as originally shown in growth factor dependent haematopoietic progenitor cell lines (e.g., FDC-P1) and in Eμ-Myc/Eμ-Bcl-2 ...

Bcl-2 is a 26-kDa protein that is part of a family of proteins involved in regulating cell death. It is located at contact sites between the inner and outer mitochondrial membranes and can inhibit cell death. You might find these chapters and articles relevant to this topic.

Mar 28, 2025 · BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

Feb 21, 2019 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been identified and some are...