Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. [5]

Myocardial wall stress, cytokines, hormones, and ischemia all stimulate B-type (or brain) natriuretic peptide (BNP) gene expression. Within the myocardium, ProBNP-108, a BNP precursor, undergoes glycosylation, after which a portion is cleaved by furin into mature BNP-32 and N-terminal proBNP-76, depending on the glycosylation status.

2004年3月20日 · Brain natriuretic peptide (BNP) is a 32 amino acid cardiac natriuretic peptide hormone originally isolated from porcine brain tissue. The human BNP gene is located on chromosome 1 and encodes the prohormone proBNP.

Currently, brain natriuretic peptide (BNP) and N -terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine.

Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac atria and ventricles, respectively. ANP signals in an endocrine and paracrine manner to decrease blood pressure and cardiac hypertrophy. BNP acts locally to reduce ventricular fibrosis.

2011年5月10日 · BNP gene transfer decreased fibrosis and increased coronary angiogenesis in normal adult rat heart and improved LV systolic function after infarction and in Ang II–induced hypertension. Remarkably, BNP gene delivery provoked favorable responses through specific context-dependent mechanisms.

BNP is a specific HIF-1alpha target gene; A single NT-pro BNP and cTnT value at 96 hours after onset of symptoms proved useful for estimation of left ventricular ejection fraction and infarct size. Plasma NT-proBNP levels can be used as a marker in …

The human gene that encodes for BNP is called NPPB (GeneID 4879) and is located on chromosome 1 at 1p36.2. In mice, NPPb is found on chromosome 4. [ 3 ] NPPB has three exons and two introns, and its preproBNP comprises 134 amino acids.

2011年5月12日 · BNP is encoded by a single gene located in the distal region of the short arm of chromosome 1. The BNP gene consists of 3 exons and 2 introns [23], [24]. In humans, transcription of the BNP gene yields a ~ 0.7 kb-long mRNA that encodes a 134-amino acid peptide, called preproBNP (see below). Exon 1 encodes the 5′-untranslated region, signal ...

Natriuretic peptide receptor 1 is probably the NP system gene studied in greatest detail at present. There is a strong accumulation of evidence that NPR1 genotype impacts phenotype, spanning from animal models to humans and from molecular to clinical phenotypes.