Beclin-1 is a protein that in humans is encoded by the BECN1 gene. [5] [6] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. …

2025年3月30日 · BECN1 (Beclin 1) is a Protein Coding gene. Diseases associated with BECN1 include Sphingolipidosis and Pancreatic Ductal Adenocarcinoma. Among its related pathways …

2019年8月21日 · 加州大学的研究人员在新研究中揭示了一个调控细胞自噬的关键分子机制，他们发现一种称作ULK1的激酶通过磷酸化Beclin-1，激活脂酶VPS34，诱导了细胞自噬发生. 这篇 …

2024年12月5日 · This report outlines the findings of all the existing research on the role of SNPs within BECN1. Autophagy is a cytoprotective process that operates within a cell to maintain …

2025年3月3日 · Using conditional gene knockout mouse models, we demonstrated that loss of Beclin 1 (Becn1), a major regulator of mammalian autophagy, exclusively in the …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

BECN1 protein expression is associated with poor survival in triple negative locally advanced breast cancer. Expression and mechanism of autophagy gene Beclin1 in tumor …

2023年3月21日 · Beclinl基因也称BECN1基因，是一种自噬相关基因，它与Bcl-2基因相互拮抗调控自噬。 自噬是细胞中初级溶酶体处理内源性底物的重要过程，同时参与维持细胞内蛋白…

编码的蛋白质是磷脂酰肌醇 3 激酶 (PI3K) 复合物的一个组分，该复合物介导囊泡运输过程。 这种蛋白质被认为在多种细胞过程中发挥作用，包括肿瘤发生、神经变性和细胞凋亡。 可变剪接 …

BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells. Despite its significant role in a …