The SYK tyrosine kinase: a crucial player in diverse ... - Nature
2010年5月14日 · Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has long been thought to exclusively mediate signalling by receptors of the adaptive immune response...
BCR 信号转导（B 细胞受体） | Cell Signaling Technology
BCR 聚集后快速激活 Src 家族激酶 Lyn、Blk 和 Fyn，以及酪氨酸激酶 Syk 和 Btk。 这就启动形成一个由 BCR 组成的“信号小体” 、上述酪氨酸激酶、 连接蛋白（如 CD19 和 BLNK），以及信 …
淋巴细胞的信号传导（上） - 知乎 - 知乎专栏
Syk是BCR信号通路的关键激酶，含有两个SH2结构域，正好识别ITAM上的两个pTyr，能识别并磷酸化下游的多种蛋白，同时自身也能被磷酸化。 CD19/CD21/CD81复合物又被称为B细胞辅助 …
Syk Mediates BCR- and CD40-Signaling Intergration during B Cell ...
In this study, we first demonstrate that CD40 ligation modifies BCR-induced B cell activation by promoting activation of Syk and formation of signaling complex consisting of Syk, Vav-2, Btk, …
The sickening consequences of too much SYK signaling
2021年3月29日 · Spleen tyrosine kinase (SYK) is one of the proteins necessary for the proper development and function of B cells. SYK has a role in transmitting signals from the...
Nature：激酶正成为炎症和自身免疫病的热门靶点（二）| 鹰谷靶 …
在B细胞中，BCR激活后将ITAM暴露给LYN/SYK/BTK，进而激活PLCγ2和 磷脂酰肌醇3-激酶 (PI3K)。 活化的PLCγ2和PI3K进而激活钙离子介导的信号通路，从而激活下游的转录因子， …
Targeting spleen tyrosine kinase (SYK): structure ... - ScienceDirect
2025年1月1日 · SYK, a key signal transducer downstream of the BCR, is considered one of the most promising targets for SLE. SYK phosphorylation was decreased after BCR activation in …
SYK-dependent tonic B-cell receptor signaling is a rational …
2008年2月15日 · Ligand-induced BCR signaling induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation, and activation of the …
Inhibition of constitutive and BCR-induced Syk activation ... - Nature
2008年12月18日 · We now report that Syk is constitutively phosphorylated on the activating Y352 residue in chronic lymphocytic leukemia (CLL) B cells. To examine the effects of constitutive …
SYK Inhibition Modulates Distinct PI3K/AKT- Dependent ... - Cell …
2013年6月10日 · In this study, we characterize distinct SYK/PI3K/AKT-dependent BCR viability pathways in DLBCL cell lines and primary tumors with high- and low-baseline NF-κB activity …