BBB Scoring is used to assess the motor function of rats. Post-injury motor behavior is assessed via the Basso, Beattie and Bresnahan (BBB) locomotor scale method [1,2]. The BBB score is …

2012年1月1日 · One assessment of locomotor function following SCI in the rat is the Basso, Beattie, and Bresnahan (BBB) scale, which is a categorical scale that subjectively documents …

2007年5月30日 · Physiological studies of the blood–brain barrier (BBB) are often performed in rats. We describe the functional characterization of a reproducible in vitro model of the rat BBB …

2014年6月28日 · We describe the implementation of a weekly reproducible protocol for the isolation and plating of brain microvessels, following purification and culture of RBEC and …

2022年8月30日 · We validated ultrasound-guided procedure in three in vivo rat brains by delivering MRI contrast agent to cortical regions of rat brains after BBB opening.

2018年5月22日 · Cell culture-based blood-brain barrier (BBB) models are useful tools for screening of CNS drug candidates. Cell sources for BBB models include primary brain …

2017年10月4日 · As several studies have highlighted the need for a well-developed, objective, and universal rating scale of functional impairments in rat models of SCI—such as the Basso, …

We have developed and characterized a new syngeneic BBB model using primary cultures of the three main cell types of cerebral microvessels. The co-culture of endothelial cells, pericytes …

The Basso–Beattie–Bresnahan (BBB) locomotor rating scale is a 21-point scale originally developed for use in rat models of thoracolumbar SCI (Basso et al., 1995). The BBB …

2009年3月1日 · In the present study we have constructed and characterized a novel BBB model consisting of the triple co-culture of primary rat brain endothelial cells, pericytes and astrocytes …