2015年5月18日 · Azathioprine (AZA) is a medication used in the management and treatment of active rheumatoid arthritis (RA) and the prevention of kidney transplant rejection. This activity reviews the indications, action, and contraindications for azathioprine as a valuable agent in treating RA and other disorders when applicable.

Azacitidine, sold under the brand name Vidaza among others, is a medication used for the treatment of myelodysplastic syndrome, myeloid leukemia, [5][6] and juvenile myelomonocytic leukemia. [4][9] It is a chemical analog of cytidine, a nucleoside in DNA and RNA. [medical citation needed] Azacitidine and its deoxy derivative, decitabine (also kn...

Azathioprine, sold under the brand name Imuran, among others, is an immunosuppressive medication. [5] . It is used for the treatment of rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus, and in kidney transplants to prevent rejection.

Pharmacodynamics. Azathioprine is an immunosuppressive agent which functions through modulation of rac1 to induce T cell apoptosis, as well as other unknown immunosuppressive functions. 5 It has a long duration of action as it is given daily, and has a narrow therapeutic index. 12 Patients should be counselled regarding the risk of …

2024年11月11日 · Azathioprine (AZA) is an immunosuppressive agent that acts through its effects as an antagonist of purine metabolism, resulting in the inhibition of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis.

2012年11月16日 · The mechanism of action (MOA) of AZA and DAC is considered to be predominantly via DNMT inhibition. However these drugs are also cytotoxic as nucleoside analogs, and AZA inhibits RNA translation and protein synthesis. Both are clinically efficacious in HR MDS but patient responses differ.

2023年5月1日 · Azathioprine (AZA) is a medication used in the management and treatment of active rheumatoid arthritis (RA) and the prevention of kidney transplant rejection. This activity reviews the indications, action, and contraindications for azathioprine as a valuable agent in treating RA and other disorders …

5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷类似物，特异型抑制 DNA 甲基化。 5-Azacytidine 与 DNA 结合共价捕获 DNA甲基转移酶 (DNA methyltransferases)，有益于逆转表观遗传变化。 5-Azacytidine 诱导细胞自噬 (autophagy)。 * Please select Quantity before adding items. • Nature. 2025 Jan;637 (8045):461-469. [Abstract] • …

Azacitidine or AZA is a pyrimidine nucleoside analog of cytidine that when incorporated into the DNA of cancer cells, decreases DNA methylation and subsequently alters gene expression regulating tumor suppression and differentiation. From: Clinical Lymphoma Myeloma and Leukemia, 2022

Constantinides P.G., Taylor S.M., Jones P.A. Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides. Dev. Biol. 1978; 66:57–71. [PubMed: 87352]