Autolysins are endogenous lytic enzymes that break down the peptidoglycan components of biological cells which enables the separation of daughter cells following cell division. [1][2][3][4][5] They are involved in cell growth, cell wall metabolism, cell division and separation, as well as peptidoglycan turnover and have similar functions to lyso...

The pneumococcal autolysin LytA is a virulence factor involved in autolysis as well as in fratricidal- and penicillin-induced lysis. In this study, we used biochemical and molecular biological approaches to elucidate which factors control the cytoplasmic …

An “autolysin” is a PG hydrolase produced and regulated by the bacterial cell for growth, division, maintenance, and repair of the PG. You might find these chapters and articles relevant to this topic.

2023年7月11日 · We show that the LytM domain of DipM interacts with multiple autolysins, including the soluble lytic transglycosylases SdpA and SdpB, the amidase AmiC and the putative carboxypeptidase CrbA, and...

2021年4月1日 · Our analyses of autolysin building blocks in eight important pathogens has already revealed intriguing patterns of sequence diversity, domain usage, and relationships among the domains comprising their lysins.

Here, we report that a major cell wall hydrolase, autolysin (Atl), controls the sorting of LukAB from the cell envelope to the extracellular milieu, an effect independent of transcriptional regulation.

The lytA-encoded autolysin (N-acetylmuramoyl-l-alanine amidase) of Streptococcus pneumoniae is believed to play an important role in the pathogenesis of pneumococcal infection and has been identified as a putative vaccine target.

2014年4月1日 · Here we report that autolysins from Gram-positive pathogenic bacteria, enzymes capable of hydrolyzing peptidoglycan, have a major role in concealing this inflammatory molecule from Drosophila peptidoglycan recognition proteins (PGRPs).

2010年1月1日 · In this event, these enzymes are called autolysins (Shockman and Höltje 1994). Autolysis is observed under conditions which result in the cessation of peptidoglycan synthesis, such as stationary phase or exposure to antibiotics, possibly from an uncontrolled action of PGHs.

Autolysins are enzymes produced by bacteria that hydrolyze the components of their own cell walls, leading to cell lysis. They play a crucial role in bacterial cell growth, division, and pathogenesis. Autolysins are vital for bacterial cell wall remodeling during growth and division.