2016年1月28日 · These are the first monkeys ever to have autism. They were genetically modified by Chinese scientists to carry a gene linked to autism in humans. According to Nature, the team says they've...

2016年1月25日 · Here we report that lentivirus-based transgenic cynomolgus monkeys (Macaca fascicularis) expressing human MeCP2 in the brain exhibit autism-like behaviours and show germline transmission of the...

2019年6月12日 · The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum ...

2016年1月25日 · Engineered to have a gene that is related to autism spectrum disorder in people, the monkeys are the most realistic animal model of the condition yet, say their creators. Researchers hope that...

2021年5月15日 · Here we induced genetic mutations in MECP2, a critical gene linked to Rett syndrome (RTT) and autism spectrum disorders (ASD), in the hippocampus (DG and CA1–4) of adolescent rhesus monkeys (Macaca mulatta) in vivo via adeno-associated virus (AAV)-delivered Staphylococcus aureus Cas9 with small guide RNAs (sgRNAs) targeting MECP2.

2019年2月15日 · We have used clustered regularly interspersed short palindromic repeat/CRISPR-associated nuclease 9 to generate a cynomolgus monkey model by disrupting SHANK3 at exons 6 and 12. Analysis of the live mutant monkey revealed the core behavioral abnormalities of ASD, including impaired social interaction and …

2016年1月25日 · Scientists in China say they used genetic engineering to create monkeys with a version of autism, an achievement that could make it easier to test treatments but that raises thorny practical and...

We report on a Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well as restricted and repetitive behaviors, along with our single-neuron and genomic analyses. Its social ability was measured in a turn-taking task, where two monkeys monitor each other’s actions for adaptive behavioral planning.

2016年1月25日 · Researchers from Shanghai have genetically modified macaque monkeys to show signs of autism, a step they hope will help develop therapies for human patients.

2020年10月15日 · Fortunately, there is a subset of rhesus monkeys within the natural population illustrating low-social behavior similar to what is observed in humans with ASD. The trick is quickly identifying enough of these animals to conduct the necessary translational research.