2025年1月21日 · Furthermore, reducing Wapl activity can bypass the need for ATRX to protect centromeric cohesion. These results provide insights into the mechanism of ATRX's …

2022年2月8日 · WAPL deficiency prevents the formation of heterochromatin domains, and allows for gene expression even in the absence of the Mediator-CDK subunit MED12. We propose …

Taken together, our findings indicate that HP1 ensures appropriate ATRX localization at the mitotic centromere, hence safeguarding centromeric cohesion and preventing chromosomal …

2020年5月6日 · We identify ATRX RNA binding regions (RBRs) and discover that the major ATRX RBR lies within the N-terminal region of the protein, distinct from its PHD and helicase …

2018年8月6日 · HP1 physically interacts with the putative ortholog of the SNF2 chromatin remodeler ATRX, which controls deposition of histone variant H3.3 in mammals. In this study, …

The need for HP1 in cohesion protection can be bypassed by centromeric targeting of Haspin or inhibiting Wapl activity. Taken together, these results reveal a redundant role for HP1α and …

2017年4月19日 · In the absence of both CTCF and Wapl, cohesin accumulates in up to 70 kilobase-long regions at 3′-ends of active genes, in particular if these converge on each other. …

2018年8月6日 · HP1 physically interacts with the putative ortholog of the SNF2 chromatin remodeler ATRX, which controls deposition of histone variant H3.3 in mammals. In this study, …

2016年4月21日 · Wapl-Pds5 does not stimulate the ATPase activity of cohesin, but requires the re-binding of ATP to nucleotide-free cohesin to open the cohesin ring. Based on this important …

ATRX deficiency causes aberrant mitosis and decreased centromeric cohesion. Furthermore, reducing Wapl activity can bypass the need for ATRX to protect centromeric cohesion.