ATG7 was identified based on homology to yeast cells Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. The protein appears to be required for fusion of peroxisomal and vacuolar membranes.

Mar 28, 2025 · ATG7 (Autophagy Related 7) is a Protein Coding gene. Diseases associated with ATG7 include Spinocerebellar Ataxia, Autosomal Recessive 31 and Fatty Liver Disease 1. Among its related pathways are Autophagy and Class I MHC …

In this review, R. Taylor, J. Collier & colleagues discuss the biological functions of the autophagy protein ATG7, and the impact of its impairment on signalling pathways and human pathology.

Mar 29, 2024 · ATG7 protein is a homodimeric E1 enzyme that mediates covalent modifications of other autophagy-related proteins during autophagy, including the binding of ATG5 and ATG12, and the lipidation...

Dec 11, 2023 · We report that autophagy-related gene 7 (ATG7) modulates p53 activity to regulate cell cycle and survival during metabolic stress, and that indicates Atg7 is functionally involved in...

Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion.

Mar 23, 2023 · We conclude that ATG7 and ATG14 are both required for restricting Mtb replication in human macrophages. Two main autophagy pathways have been implicated in host defence against intracellular...

Aug 13, 2020 · In this study, we investigated the role of ATG7, an essential autophagy regulator with no autophagy-unrelated functions, in the mechanism of EC inflammation and permeability.

Feb 13, 2025 · Single-cell RNA sequencing, biochemical, and immunofluorescence analyses revealed that Atg7 deficiency reduces unfolded protein response (UPR) while increasing oxidative stress. Cellular assays demonstrated that these changes …

Jun 23, 2021 · We found deleterious, recessive variants in human ATG7, a core autophagy-related gene encoding a protein that is indispensable to classical degradative autophagy. Twelve patients from five...