Atg5是参与自噬泡中吞噬细胞膜延伸的关键蛋白，它与Atg12形成组成型的复合物。 在此过程中，首先Atg7作为类E1泛素活化酶激活Atg12；然后Atg12被传递给类E2泛素转移酶Atg10；最后Atg12与Atg5结合形成复合物。

Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.

Atg 基因通过 Atg12-Atg5 以及 LC3-II (Atg8-II) 复合体，控制自噬体的形成。 Atg12 通过一个需要 Atg7 和 Atg10（分别对应 E1 和 E2 样酶）参与的泛素样反应，结合到 Atg5。

我们在昆虫细胞中的研究发现，全长的ATG5 (相对分子质量31 000)能调控细胞自噬进程，而截短分子ATG5－tN (相对分子质量24 000)则具有触发细胞凋亡的作用，这些结果为ATG5在昆虫细胞自噬和凋亡中的重要作用奠定了基础，但对ATG5调控昆虫细胞自噬触发凋亡的分子 ...

2025年3月28日 · ATG5 (Autophagy Related 5) is a Protein Coding gene. Diseases associated with ATG5 include Spinocerebellar Ataxia, Autosomal Recessive 25 and Stomatitis. Among its related pathways are Autophagy and Selective autophagy. Gene Ontology (GO) annotations related to this gene include Atg8-family ligase activity.

2025年1月15日 · Here, we find that the core autophagy protein ATG5 regulates PC survival beyond its conventional role in clearing protein aggregates and mitochondria. Instead, ATG5 acts neuroprotective by...

该基因编码的蛋白质与自噬蛋白 12 结合，在泛素样结合系统中起 E1 样激活酶的作用。 编码的蛋白质参与多种细胞过程，包括自噬囊泡形成、氧化损伤后线粒体质量控制、先天抗病毒免疫反应的负调节、淋巴细胞发育和增殖、MHC II 抗原呈递、脂肪细胞分化和细胞凋亡。 已发现该基因的几种转录变体编码不同的蛋白质亚型。 [RefSeq 提供，2015 年 9 月] The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating Enzyme in …

2022年9月5日 · ATG5, a key component of autophagy, regulates the formation of the autophagosome, a hallmark of autophagy. ATG5 binds with ATG12 and ATG16L1 resulting in E3 like ligase complex, which is necessary for autophagosome expansion.

2006年10月1日 · Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. However, it has now been shown that, in...

ATG5 nonautophagically regulates inflammation and differentiation in mouse embryonic stem cells. Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.