2024年12月6日 · This is an impressive study by Serrano-Pozo, Hyman, Das and colleagues that explores astrocyte transcriptomic molecular programs in aging and Alzheimer’s Disease. Using single-nucleus RNA sequencing of more than 600,000 astrocytes from five brain regions, the authors characterized astrocyte phenotypes ranging from normal aging to severe AD.

2022年6月30日 · The adage of astrocytes as doting neuronal nursemaids has been supplanted by the view that astrocytes play a muscular part in the function of the brain. Provoke them, and astrocytes can shift from supporter to destructor. Two new studies examined different reactive states astrocytes adopt in response to inflammatory stimuli, and which transcriptional …

2023年9月20日 · In six different neurodegenerative diseases, reactive astrocytes suppress TMEM164. This astrocyte receptor maintains homeostasis, preventing release of toxic lipids. Overexpressing TMEM164 preserved neurons in mouse models of AD and PD.

2021年11月9日 · In the October 26 Science Signaling, they reported that adding gemfibrozil and retinoic acid to mouse astrocyte cultures spurred clearance of Aβ. The drugs increased expression of LDL receptors and prodded lysosome activity in the cells.

2023年6月2日 · The use of longitudinal tau measures provides evidence that tau accumulation is a downstream event compared to amyloid and astrocyte activation. However, it is not clear whether astrocyte activation precedes, follows, or develops independently of …

2023年10月4日 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach for treating neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

2024年12月5日 · “The astrocyte response to AD neuropathology is complex and nonlinear, both along spatial and temporal axes,” Das told Alzforum. She hopes the dataset, which is freely available online, will be a useful resource for future astrocyte studies. Eduardo Zimmer at the Federal University of Rio Grande do Sul, Porto Alegre, Brazil, thinks the paper helps banish …

2020年11月18日 · Richetin found that within these astrocytes, mitochondria languished in the cell bodies, rather than travelling to the astrocyte arms that support neurons. Mitochondrial function also suffered; the organelles replenished less often, and …

04 Nov 2023 In their growing interest in the brain's border tissues, Alzheimerologists realize that they know little about some of its cells. One new study now sheds light on the astrocytes that form the glia limitans, which separates the brain's parenchyma from its meninges. Scientists led by Philip Hasel and Shane Liddelow at New York University used a combination of single-cell …

2020年6月5日 · The scientists identified a cell-surface marker, CD49f, that can be used to sort human astrocytes from cultured neurons, microglia, and oligodendrocytes. The sorted cells’ expression profile matched that of astrocytes in human brain, and they exhibited classic astrocyte behaviors in culture. When stimulated with pro-inflammatory cytokines, they became reactive …