Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1 , a member of the …

Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial roles on a spectrum of developmental and physiological processes. The biological actions of estrogens …

2023年1月26日 · Aromatase inhibitors are drugs used to prevent cancer recurrence in women with estrogen-sensitive breast cancer. Learn about dosages and side effects.

Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced oestrogens in the differentiation, regulation and normal function of several organs and …

Aromatase catalyzes three separate steroid hydroxylations involved in the conversion of androstenedione to estrone. The first two give rise to 19-hydroxy and 19-aldehyde structures, …

Aromatase is the rate-limiting enzyme in estrogen biosynthesis (Simpson & Santen 2015). The biologically active estrogen, 17β-estradiol (E2), exerts its actions by binding to its receptors, …

Aromatase is an enzyme that converts androgens into estrogens, and aromatase inhibitors (AIs) can eliminate the production of estrogen. Furthermore, antiestrogens can bind to ER and …

Aromatase is a member of the cytochrome P450 superfamily that catalyzes the conversion of androgens (C(19)), namely testosterone and androstenedione, into oestrogens (C(18)), …

These sites include breast, bone, vasculature, and brain. Within these sites, aromatase action can generate high levels of estradiol locally without significantly affecting circulating levels. …

Aromatase (estrogen synthetase; EC 1.14.14.1) catalyzes the demethylation of androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely known for its …