Accumulation of APP-CTF induces mitophagy dysfunction in the …
2022年1月10日 · We demonstrated the effects of APP-CTFs-related pathology using induced neural stem cells (iNSCs) from AD patient-derived fibroblasts. APP-CTFs accumulation was …
C-terminal fragments of the amyloid precursor protein in ... - Nature
2017年5月30日 · In this study we investigated if APP-CTFs are detectable in CSF, characterized the major APP-CTF immunoreactive band, and determined whether the levels of this peptide …
APP β-CTF triggers cell-autonomous synaptic toxicity ... - eLife
APP, a type I transmembrane protein, undergoes cleavage primarily by α-secretase on the cytoplasmic membrane, producing soluble α-cleavage N-terminal fragment (sAPPα) and α …
Accumulation of amyloid precursor protein C-terminal ... - Springer
2020年10月20日 · Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of …
Accumulation of APP C-terminal fragments causes endolysosomal ...
2024年6月17日 · Our findings imply a critical role for balanced APP-CTF levels in LE/Lys-ER membrane contact sites (MCSs) to maintain endolysosomal homeostasis. The detrimental …
Neuronal lysosomal dysfunction releases exosomes harboring APP …
2018年1月18日 · Our results reveal a homeostatic response counteracting lysosomal dysfunction via secretion of atypical exosomes eliminating lysosomal waste and define exosomal APP …
Intraneuronal aggregation of the β-CTF fragment of APP (C99) …
By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrate a link between EAL pathology and the intraneuronal accumulation of the β-secretase-derived …
Accumulation of amyloid precursor protein C-terminal fragments …
Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's disease (AD) …
Acta Neuropathologica: 淀粉样前体蛋白C末端片段的 ... - MedSci
2020年10月23日 · 在这里，我们证明在神经母细胞瘤SH-SY5Y细胞中，表达APP瑞典突变或β-分泌酶衍生的APP-CTF片段（C99）结合β-和γ-分泌酶抑制，APP-CTF的积累独立于Aβ触发过 …
脑脊液中淀粉样蛋白前体蛋白的C末端片段可作为阿尔茨海默氏病 …
使用针对特定结构域的特异性抗体的多重荧光成像，通过蛋白质印迹免疫沉淀和同时测定，来表征人CSF中APP的CTF。 我们证明APP-CTFs在人类脑脊液中是可检测到的，是最丰富的25 kDa …