2025年3月30日 · AHCY (Adenosylhomocysteinase) is a Protein Coding gene. Diseases associated with AHCY include Hypermethioninemia With S-Adenosylhomocysteine Hydrolase Deficiency and Hypermethioninemia. Among its related pathways are L-methionine degradation I (to L-homocysteine) and Peptide chain elongation.

2021年3月31日 · Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. In mammals, AHCY is the only enzyme capable of performing this reaction.

2024年5月29日 · AHCY is the gene that encodes the enzyme adenosylhomocysteinase. In mammals, AHCY is the only enzyme that can convert SAH to homocysteine, and it can also catalyze the reverse conversion of homocysteine to SAH. This makes it a key enzyme in a fundamental cellular pathway found in all animals.

它催化 S-腺苷高半胱氨酸 (AdoHcy) 可逆水解为腺苷 (Ado) 和 L-高半胱氨酸 (Hcy) 。 因此，它调节细胞内 S-腺苷高半胱氨酸 (SAH) 浓度，该浓度被认为对转甲基反应很重要。 这种蛋白质的缺乏是高甲硫氨酸血症的不同原因之一。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 6 月] S-adenosylhomocysteine hydrolase belongs to …

The AHCY gene provides instructions for producing the enzyme S-adenosylhomocysteine hydrolase. This enzyme is involved in a multistep process that breaks down the protein building block (amino acid) methionine.

2020年5月6日 · AHCY mutations (R49C, D86G, Y143C, W112X and A89V) in humans lead to greatly elevated levels of S-adenosylhomocysteine (>100-fold), causing early developmental stagnation and severe ...

2020年4月23日 · 腺苷同型半胱氨酸水解酶（Adenosylhomocysteinase, AHCY）是甲硫氨酸代谢途径中重要的代谢酶，它催化硫代腺苷同型半胱氨酸（S-adenosylhomocysteine, SAH）水解产生腺苷（adenine）和同型半胱氨酸（homocysteine）。 值得注意的是，其产物SAH能通过底物抑制的方式抑制细胞内的甲基转移酶活性，进而调控细胞内的转甲基反应（9）。...

2025年1月1日 · AHCY基因，全名为adenosylhomocysteinase，也被称为SAHH或AdoHcyase。 这个基因位于人类染色体的20q11.22位置，是一个编码蛋白质的基因。 AHCY基因的主要功能是编码一种叫做腺苷同型半胱氨酸酶的蛋白质

2017年9月1日 · AHCY deficiency (OMIM #613752) in humans involves serious biochemical aberrations, retarded psychomotor development, myopathy and myelination disorders (Baric et al., 2004, Barić et al., 2005), and is potentially lethal in early stages of life (Baric et al., 2004, Barić et al., 2005, Vugrek et al., 2009).

2024年3月13日 · Adenosylhomocysteinase (AHCY), a key enzyme in the methionine cycle, is essential for the development of embryos and the maintenance of mouse embryonic stem cells (mESCs). However, the precise underlying mechanism of Ahcy …