ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly (ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases.

2018年2月14日 · ADP-ribosylation—the transfer of ADP-ribose (ADPr) from NAD+ onto target molecules—is catalyzed by members of the ADP-ribosyltransferase (ART) superfamily of proteins, found in all...

Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades ...

2023年10月12日 · ADP-ribosylation of proteins and nucleic acids regulates various cellular functions in all kingdoms of life, and its manipulation holds potential for human therapeutics. 60 years after the discovery of ADP-ribosylation, this review provides state-of-the-art insights on structural biology, biochemistry, cell biology, and clinical aspects.

ADP-ribosylation is the process of adding an ADP-ribose moiety onto a protein using NAD as a substrate, leading to mono- or poly- (ADP-ribosyl)ation. This modification plays a crucial role in DNA damage response and chromatin structure regulation.

ADP-ribosylation is a post-translational modification involved in DNA damage response (DDR). In higher organisms it is synthesised by PARP 1–3, DNA strand break sensors. Recent advances have identified serine residues as the most common targets for ...

2019年4月17日 · ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which controls major cellular and biological processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress and immune responses.

ADP-ribosylation is a chemical modification of macromolecules found across all domains of life and known to regulate a variety of cellular processes. Notably, it has a well-established role in the DNA damage response.

2024年5月11日 · ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids. This modification is broadly categorized as Mono (ADP-ribosyl)ation (MARylation) or poly (ADP...

2023年10月12日 · ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.