2022年12月29日 · Reciprocally, protein acylation is involved in key cellular processes relevant to physiology and diseases, such as protein stability, protein subcellular localization, enzyme activity,...

Protein acetylation (and deacetylation) are acetylation reactions that occur within living cells as drug metabolism, by enzymes in the liver and other organs (e. g., the brain). Pharmaceuticals frequently employ acetylation to enable such esters to cross the blood–brain barrier (and placenta ), where they are deacetylated by enzymes ...

In this regard, Nakayasu and co-workers demonstrated that some glycolytic and TCA cycle enzymes are acetylated on highly conserved lysine residues located within the catalytic pocket of the enzyme. This modification dramatically alters the charge and shape of the lysine residue by neutralizing its positive charge and increasing its size, which ...

A large proportion of metabolic enzymes are acetylated. Mitochondrial proteins (in blue) and cytoplasmic proteins (in green) that have been found acetylated in M. musculus are overlaid on the KEGG Metabolic Pathways reference pathway.

2018年11月22日 · Acetylation affects protein functions through diverse mechanisms, including by regulating protein stability, enzymatic activity, subcellular localization and crosstalk with other...

2021年12月1日 · Protein acetylation is an evolutionarily conserved posttranslational modification. It affects enzyme activity, metabolic flux distribution, and other critical physiological and biochemical processes by altering protein size and charge.

2010年2月19日 · We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus gluconeogenesis and the branching between ...

2015年10月27日 · In this Review, we examine the role of reversible acetylation in metabolic control and how changes in levels of metabolites or cofactors, including nicotinamide adenine dinucleotide, nicotinamide,...

Acetylation refers to a reversible modification on proteins, particularly lysine residues in histone proteins, that can influence chromatin structure and gene expression levels. This process is extensively studied in molecular and cell biology, although the functional consequences of acetylation on other proteins are not well understood.

We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue.