2015年4月4日 · AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the …

AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocytic and secretory …

GAK is a known association partner of cyclin G and CDK5, some of its known functions are shared with AAKl. GAK is necessary for reticulin transport, and mediates the binding with …

AAK1 and GAK, the cyclin G-associated kinase, phosphorylate the μ subunits of both AP-1 and AP-2 trafficking adaptors (21, 22, 25). AAK1, via phosphorylation of Thr-156 of the μ2 subunit, …

Host kinases AAK1 and GAK regulate entry, assembly, and/or release of multiple RNA viruses through phosphorylation of the membrane trafficking adaptors AP1 (pink) and AP2 (purple). …

2021年9月26日 · Recently, two proteins that regulate CME – AAK1 and GAK – have been proposed as potential therapeutic targets for designing broad-spectrum antiviral drugs. In this …

AAK1 and GAK regulate core-AP2M1 binding and are essential for HCV assembly. A. Regulatory mechanisms of AP2M1 binding to host cargo proteins harboring YXXΦ signals. B. Binding of …

AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocytic and secretory...

As nouns the difference between gak and aak is that gak is the drug crystal meth while aak is a flat cargo vessel used on the lower rhine. As an interjection gak is expressing disgust or …

2018年5月1日 · We have demonstrated that treatment with sunitinib and erlotinib, approved anticancer drugs with anti-AAK1 or GAK activity, is effective in inhibiting replication of Ebola, …