MSH2 and ATR form a signaling module and regulate two …
In this study, we report a MSH2-dependent signaling pathway in response to DNA damage caused by MNNG. We found that MSH2 protein interacts with the ATR kinase constitutively to …
The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation …
2015年8月20日 · Here, we identify the mismatch-binding protein MutSβ, a heterodimer of MSH2 and MSH3, as a key player in this process. MSH2 and MSH3 form a complex with ATR and its …
Structural, molecular and cellular functions of MSH2 and MSH6 …
Two different mechanistic models leading to MMR-dependent cell death have been proposed. The signaling model proposes direct activation of the ataxia-telangiectasia mutated and Rad3 …
Mechanisms and regulation of DNA end resection in the ... - Nature
2025年3月25日 · ATM and ATR promote resection in response ... The function of EXO1 in DNA end resection is promoted by the mismatch repair heterodimer MSH2–MSH3, which is …
In this study, we report a MSH2-dependent signaling pathway in response to DNA damage caused by MNNG. We found that MSH2 protein interacts with the ATR kinase constitutively to …
Functional interplay between ATM/ATR-mediated DNA damage …
2014年6月20日 · MMR crosstalks with ATM/ATR pathways in response to oxidative DNA damage. Mismatch pairs with damaged base are recognized by MutSα (MSH2 and MSH6) …
Cell-cycle and DNA damage regulation of the DNA mismatch …
2013年2月1日 · Using a luciferase-based transcriptional reporter, we defined a 218-bp region upstream of MSH2 that contains cell-cycle and DNA damage responsive elements. The 5′ end …
MSH2 and ATR form a signaling module and regulate two …
2003年12月23日 · We report that MSH2 (MutS homolog 2) protein interacts with the ATR (ATM- and Rad3-related) kinase to form a signaling module and regulate the phosphorylation of Chk1 …
MSH2 and ATR form a signaling module and regulate two branches …
2004年1月1日 · We report that MSH2 (MutS homolog 2) protein interacts with the ATR (ATM- and Rad3-related) kinase to form a signaling module and regulate the phosphorylation of Chk1 and …
Mismatch repair proteins play a role in ATR activation upon ...
2022年4月6日 · Here, we demonstrate that MSH2, MSH6, MLH1 and PMS2, specifically, are involved in the activation of the ATR axis after TMZ exposure, whereas MSH3 is likely not.