腺苷酸转运体 （adenine nucleotide translocator， ANT ） 位于线粒体内膜，其表面存在ATP和ADP的结合位点，是负责线粒体基质和细胞浆之间ADP/ATP转换的转运蛋白。 在正常生理状态下，ADP/ATP 的交换遵循 Michaelis-Menten 动力学，...

2017年3月20日 · As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine...

2019年10月16日 · Disease-causing human mutations in ANT1 abrogate binding to TIM44 and TIM23 and inhibit mitophagy. Together, our findings show that ANT is an essential and fundamental mediator of mitophagy in...

ADP/ATP 交换相关突变 Ant1 (K43E/R244E) 能有效挽救线粒体自噬，保留 ADP/ATP 交换的疾病突变体 Ant1 (A90D),ANT1 (A123D) 不起作用。 因此，ANT 促进线粒体自噬不依赖于ADP/ATP 交换活性。 ANT 的缺失抑制 PINK1 依赖的氧化应激以及氧化磷酸化毒性引起的线粒体自噬，表明 ANT 在 PINK1 的上游起作用。 正常情况下，PINK1 会被胞质蛋白酶体组成型降解。 但当线粒体受损后，TIM23 介导的转运被抑制，使 PINK1 逃逸降解，并将 Parkin 募集到线粒体。 ANT1 或 …

ANT1的主要功能包括介导线粒体ATP/ADP的转运,介导解偶联和质子泵。 作为线粒体转运体家族的一员,ANT1可以介导线粒体内合成的ATP 转出至胞浆和胞浆内ADP转入线粒体,这种ATP/ADP 的交换是ATP合成过程的重要保证。 此外,ANTl还与位于线粒体外膜的电压依赖性离子通道(VDAC)和亲环蛋白D(CyP—D)等构成线粒体膜通透性转换孔(MPTP)复合体。 We thank Prof. Jingchu Luo for his work on lectures and interesting stories. We like the stories as well as the knowledge.

2020年7月1日 · ANT proteins exchange ATP/ADP across the inner-mitochondrial membrane. ANTs can generate mitochondrial permeability transition pore (MPTP) activity. MPTP is comprised of multiple proteins and has both ANT and non-ANT pores. ANT proteins are also involved in mitochondrial H + leak and mitophagy.

2022年8月1日 · Adenine Nucleotide Translocator isoforms (ANTs) exchange ADP/ATP across the inner mitochondrial membrane, are also voltage-activated proton channels and regulate mitophagy and apoptosis. The ANT1 isoform predominates in heart and muscle while ANT2 is systemic. Here, we report the creation of Ant mut …

2016年1月1日 · ANT1 overexpression increases HIF-1α and induction of the anaerobic pathway, stabilizing the intracellular ATP content. Inhibition of ERK1/2, AKT phosphorylation, or ANT activity eliminates cell protection in ANT1-transgenic cardiomyocytes.

The FA anions slide alongside the electrostatic surface potential of ANT1; its modulation by binding ADP/ATP specific substrates inhibits the FA anion transport (Circle 3, red). The inhibition of ANT1-mediated proton leak is the strongest for the ANT1 substrates—ADP and ATP.

2021年8月19日 · Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. This study analyzed the role of ANT1 in the immune response of ischemic heart tissue.