2021年11月8日 · The urinary albumin-to-creatinine ratio (UACR) peaked at 8 weeks of age in ADR-injected CT (ADR CT) mice. The UACR in ADR-injected Tg (ADR Tg) mice was significantly lower than that of ADR CT...

2018年2月28日 · Both ADR resistant (C57BL/6) and susceptible (BALB/C) strains were part of the induced nephropathy with ADR injection. BALB/C mice significantly presented increased urinary albumin/creatinine ratio (UACR) with renal lesions in pathology, but C57BL/6 mice were absent from kidney damage.

2025年1月7日 · Adriamycin (ADR), one of the most widely used chemotherapeutic drug, is also a well-known toxic agent of renal injury, which mimics histological changes and causes...

利用代谢笼收集小鼠的24 h尿液，分别检测注射前和注射14 d时2组小鼠尿白蛋白肌酐比值（urinary albumin creatinine ratio，UACR）；在第15日处死小鼠，收集小鼠肾脏组织标本，通过蛋白印迹法检测ADR诱导小鼠肾病模型中METTL10和足细胞标志物包括synaptopodin、nephrin …

2024年6月14日 · The urinary albumin/creatinine ratio (UACR) and blood urea nitrogen (BUN) concentration were significantly greater in ADR-treated mice than in control mice (Figure 8A and B), indicating the successful establishment of ADR nephropathy.

2024年7月15日 · Then, we discovered that ADR group displayed an increased level of urine albumin-to-creatinine ratio (UACR) compared with ND group, and further elevated in HFD group after ADR administration (Fig. 1 e).

2025年1月7日 · Mouse model was established by Adriamycin(ADR) and urinary albumin/ creatinine ratio(UACR) was detected. Murine podocyte cell line was stimulated with ADR. We determined METTL10 was one of the significantly downregulated genes in damaged podocytes, confirmed the decreased glomerular expression of METTL10 in patients with idiopathic FSGS and in ...

We measured albuminuria in adult wild type (WT) and Keap1FA/FA mice in the absence of experimental injury. Both groups had low urine albumin-to-creatinine ratios (UACR) (Figure 1a). Keap1FA/FA mice exhibited normal glomerular histology and …

Mouse model was established by Adriamycin(ADR) and urinary albumin/ creatinine ratio(UACR) was detected. Murine podocyte cell line was stimulated with ADR. We determined METTL10 was one of the significantly downregulated genes in damaged podocytes, confirmed the decreased glomerular expression of METTL10 in patients with idiopathic FSGS and in ...

To test the hypothesis that the dysbiosis in the gut microbiome accompanied by inflammation can cause proteinuria, we analyzed the gut microbiome profile in the Adriamycin (ADR)-induced nephropathy in BALB/C mice, which was an ADR susceptible strain, as well C57BL/6, an ADR resistant strain that served as a control.