A23187 is a mobile ion-carrier that forms stable complexes with divalent cations (ions with a charge of +2). A23187 is also known as Calcimycin, Calcium Ionophore, Antibiotic A23187 and Calcium Ionophore A23187. It is produced at fermentation of Streptomyces chartreusensis.

Calcium ionophore A23187 is a carboxylic acid antibiotic with weak in vitro activity against Gram-positive organisms. It increases the potential of divalent ions to cross biological membranes, thus it acts as an ionophore.

2025年4月2日 · The calcium ionophore A23187 (Calcimycin) is an antibiotic that induces Ca 2+-dependent cell death by increasing intracellular concentrations of calcium ions. It is a commonly used biochemical and pharmacological tool due to its multiple, unique biological effects (1).

2019年7月26日 · Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits …

Antibiotic A23187 | C29H37N3O6 | CID 40486 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The dose-dependent induction of platelet aggregation, dense granule secretion and thromboxane formation by the divalent cation ionophores A23187 and ionomycin were compared in citrated platelet rich plasma (PRP), and measured simultaneously with the increases in cytosolic Ca(2+) levels in aequorin-l …

Protocol to analyze lipid asymmetry in the plasma membrane. A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.