2023年2月6日 · These data identify mAbs suitable for detecting 5T4 in formalin-fixed, paraffin-embedded tissues and demonstrate both interpatient and histologic subtype heterogeneity. Our validated 5T4 IHC protocol will facilitate biomarker studies …

The 5T4 oncofoetal antigen was identified by searching for surface molecules shared between human trophoblast and cancer cells with the rationale that they may function to allow survival of the foetus as a semi-allograft in the mother or a tumour in its host.

2024年11月28日 · 癌胎抗原5T4，又称滋养层糖蛋白(trophoblast glycoprotein )TPBG，也称为Wnt 激活抑制因子 1（WAIF1）。是一种分子量为72kd, 由TPBG基因编码的N端高度糖基化的I型跨膜蛋白，属于富含亮氨酸重复序列 (LRR) 超家族。

In this present study, we have performed bioinformatics analysis to demonstrate 5T4 mRNA expression in both adenocarcinoma and squamous cell carcinoma of lung. Using 5T4-specific antibodies, we developed an IHC assay to detect 5T4 in NSCLC and an immunofluorescence assay to detect 5T4 in CTCs.

A trophoblast cell surface antigen has been characterised by a monoclonal antibody (mAb) 5T4, raised following immunisation with solubilised wheat germ agglutinin binding glycoproteins from human syncytiotrophoblast plasma membrane (StMPM).

2005年9月13日 · The 5T4 oncofoetal antigen is a heavily glycosylated cell surface protein found on human placental trophoblast and on diverse types of human cancer but is not expressed at significant levels on...

结果 IHC 分析证实了 5T4 在 HNSCC 口腔活检组织中的表达，包括来自原发性肿瘤、复发性肿瘤的标本和淋巴结转移。 患者来源的 HNSCC 细胞系 (n=22) 在质膜上表现出 5T4 表达，每个细胞有 10,000 - 61,000 个 5T4 分子。 此外，5T4 表达在来自新鲜分离的 HNSCC 活检的单细胞悬液中的 EGFR+CD45-肿瘤细胞上很明显，与肿瘤部位无关。 DuoBody-CD3x5T4 表现出强效，在测试的 5T4 表达水平范围内，健康供体 T 细胞和患者来源的 HNSCC 细胞系的体外共培养物中的靶标 …

2023年1月3日 · ALG.APV-527 is uniquely designed for 5T4-conditional 4–1BB–mediated antitumor activity with potential to minimize systemic immune activation and hepatotoxicity while providing efficacious tumor-specific responses in a range of 5T4-expressing tumor indications as shown by robust activity in preclinical in vitro and in vivo models.

2016年10月18日 · The 5T4 oncofoetal antigen was identified by searching for surface molecules shared between human trophoblast and cancer cells with the rationale that they may function to allow survival of the foetus as a semi-allograft in the mother or a tumour in its host.

2020年9月25日 · The use of 5T4 antibody-drug conjugates selectively targeting 5T4-positive tumor-initiating cells in combination with chemotherapy has shown considerable promise in preclinical studies. Further clinical investigations are needed to focus the use of 5T4-specific immunotherapies in the management of particular cancers.