3-monochloropropane-1,2-diol esters (3-MCPDE) and glycidyl esters (GE) are contaminants that can occur in edible oils, such as vegetable oils, and foods made from these oils. Both food...

Jan 10, 2018 · The chemical 3-monochloropropane diol (3-MCPD) and related substances called 3-MCPD esters are food processing contaminants found in some processed foods and vegetable oils, mainly palm oil. 3-MCPD and its esters are formed unintentionally in these foods, in particular during oil refining processes.

What is 3-MCPD? 2- and 3-MCPD (free 2- and 3-monochloropropanediols (in short 3-MCPD) are substances that arise when oils and fats that are rich in salts are heated for too long and/or at too high tem-peratures. The amount of 3-MCPD that arises depends on the temperature to which the oil or fat is heated and the duration of the exposure.

Oct 25, 2016 · This paper presents an overview of current knowledge about 3-MCPD, including its formation routes, occurrence in various foodstuffs, analytical approach, toxicological aspects, and future research perspectives.

No genotoxic potential has been demonstrated in vivo for 3-MCPD. Two long-term carcinogenicity studies with 3-MCPD in rats were identified as pivotal studies, and renal tubular hyperplasia was identified as the most sensitive end-point.

3-Chloro-1,2-propanediol (3-MCPD) is present as contaminants in different foods. 3-MCPD is a non-genotoxic compound exhibiting secondary carcinogenic effects. 3-MCPD also induce nephrotoxicity, reproductive toxicity and other toxic effects. EFSA derived a tolerable daily intake of 2 μg/kg body weight and day in 2018.

3-monochloropropane 1,2-diol (3-MCPD) is a carcinogenic contaminant of acid hydrolysed vegetable protein (acid-HVP), producing genotoxic intermediates on metabolism such as epoxide glycidol.

Mar 23, 2023 · The 3-MCPD caused the collapse of mitochondrial membrane potential (MMP), with an increase in the reactive oxygen species (ROS), where the cell death signals activation without changing the quantity of reduced glutathione in the body.

3-MCPD is the most commonly occurring group of contaminants known as chloropropanols. First identified as a contaminant of acid-hydrolysed vegetable proteins and soy sauce, it was later found in other foods. 3-MCPD and its esters can be formed in heat-processed fat-containing foods from glycerol or acyl glycerides, in the presence of chloride ions.

Jun 10, 2024 · 3-Monochloropropane-1,2-diol (3-MCPD) is a chloropropyl alcohol contaminant mainly from the thermal processing of food and could affect kidneys. Pyroptosis is programmed cell death mediated by inflammasomes and gasdermins, and excessive cellular pyroptosis and inflammation can lead to tissue injury. …