25I-NBOMe, also known as 2C-I-NBOMe, Cimbi-5, and shortened to "25I", is a psychedelic drug of the phenethylamine, 2C, and NBOMe (25-NB) families. Since 2010, it has circulated in the recreational drug scene, often misrepresented as LSD. [5]

25I-NBOMe是一种 苯乙胺 类化合物衍生的致幻化合物。 属于2C-I家族。 由化学家 Ralf Heim于2003年在 柏林自由大学 首先发现 [1]。 是首个发现是5-HT2 受体 完全 激动剂 [2]。 25I-NBOMe就像其他的2C-X-NBOMe类化合物一样，25I-NBOMe是苯乙胺2C家族的衍生物。 苯乙胺2C家族的衍生物由 亚历山大·西奥多·舒尔金 首先在PIHKAL中做了详细的描述 [3-4]。 25I-NBOMe是苯乙胺2C家族的N-苄基衍生物。 它是在 苯乙胺 2C家族化合物骨架结构的N端连接上2-甲氧基苄基而 …

25i-NBOMe 到底有什么危害？ 据英国《每日电讯》9月14日报道，一位澳大利亚16岁的少年服用中国制造的合成致幻剂后，在迷幻状态下跳楼身亡。 他的父亲布里奇伪装成有意购买的“澳洲黑帮大…

2023年7月12日 · NBOMe (N-bombs) are a class of psychedelic drugs within the greater phenethylamine family. There are dozens of different NBOMe compounds in this group, but the most common, by far, is a chemical called 25I-N-BOMe. These compounds work through the same mechanisms as LSD, DMT, psilocybin, and mescaline.

25I-NBOMe (also known as 2C-I-NBOMe, NBOMe-2C-I, Cimbi-5, Smiles, and one of many drugs referred to as N-Bomb) is a novel psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects …

The most frequently reported drugs from this group are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. NBOMe compounds are ultrapotent and highly efficacious agonists of serotonin 5-HT 2A and 5-HT 2C receptors (Ki values in low nanomolar range) with more than 1000-fold selectivity for 5-HT 2A compared with 5-HT 1A.

2022年2月1日 · 5-HT2A receptor (e.g. 25I-NBOMe) agonists not only pose risks of acute intoxication but also long-term effects and significant adverse reactions, e.g. hallucinogen persisting perception disorder (HPPD), derealization, and depersonalization. We evaluated the risk associated with single and repeated use of 25I-NBOMe.

NBOMes are N-benzylmethoxy derivatives of the 2C family hallucinogens. 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is one of the commonly used illicit drugs. It exhibits high binding affinity for 5-HT2A/C and 5-HT1A serotonin ...

2022年2月21日 · Injections with 25I-NBOMe (encoded as 25I-NBMeO) at doses 0.1, 0.3, and 1 mg/kg significantly decreased the number of surviving BrdU+ cells and BrdU/NeuN+ neurons in the hippocampus in...

2024年4月30日 · Also known as N-bomb, Solaris, Wizard, and Smiles, 25i is one of the derivatives of N-methoxybenzyl-methoxyphenylethylamine (NBOMe). This is a class of intoxicating and often deadly substances that made their way into the U.S.’s illicit drug market in 2010, although the drug 25i itself was first noticed by officials in 2011 around Virginia.