2019年11月8日 · KALM-1 was a randomized, double-blind, placebo-controlled, phase 3 trial that was conducted at 56 sites in the United States; an open-label extension phase to evaluate longer-term safety is ongoing.

2024年10月29日 · 分享一下我们NeurIPS 2024 大语言模型 驱动强化学习的工作KALM：《Knowledgeable Agents by Offline Reinforcement Learning from Large Language Model Rollouts》。 这项工作由@俞扬老师指导，和杨思航、李开元等几位同门一起完成。 我们提供了一种全新的大语言模型（LLM）做底层控制的思路：基于LLM直接生成控制数据。

2020年1月16日 · The imputed percentage of patients with a decrease of at least 3 points in the WI-NRS score was 49.1% in the difelikefalin group, as compared with 27.9% in the placebo group (P<0.001). Difelikefalin also resulted in a significant improvement from baseline to week 12 in itch-related quality of life as measured by the 5-D itch scale and the ...

2023年4月13日 · 4.3.1. KALM-1 and KALM-2 studies [Citation 30] KALM-1 was a double-blind, placebo-controlled, phase 3 trial. Hemodialysis patients with moderate-to-severe pruritus were randomly assigned to receive either IV difelikefalin (0.5 µg/kg) or placebo three times per week for 12 weeks, with an additional open-label extension of 52 weeks. The primary ...

2022年6月28日 · KALM-1 and KALM-2 were conducted in accordance with ethical principles founded in the Declaration of Helsinki, International Council for Harmonization principles of Good Clinical Practice, and applicable regulations of the countries in which the studies were conducted. Institutional review boards or independent ethics committees reviewed and ...

KALM enables LLM to imagine novel rollouts unseen before. In (a), LLM is never trained with data containing "wall", but it raises the robotics arm to avoid colliding the wall. In (b), LLM is only trained with goals like "move blue ball to the left of red ball." Takeaways 1. LLMs can generalize novel execution rollouts, after fine-tuned with low ...

2022年3月2日 · 欧盟CHMP的积极意见、以及美国 FDA 的批准，均基于2项关键3期临床试验（KALM-1，KALM-2）的阳性数据，以及来自额外32项临床研究的支持性数据。 在3期 临床试验中 ， 伴有中度至重度CKD-aP的血液透析患者，接受Korsuva注射液治疗后，瘙痒强度和生活质量指标均表现出统计学意义的显著改善。

2021年8月25日 · 在KALM-1试验中，伴有中度至重度CKD-aP的血液透析患者，接受Korsuva注射液治疗后，瘙痒强度和生活质量指标均表现出统计学意义的显著改善。 difelikefalin（CR845）是首个（first-in-class）KOR激动剂，对人体外周神经系统和某些免疫细胞具有调节作用。

The First Kalma is known as the Kalma Tayyibah (The Pure Word). It is a declaration of faith that emphasizes the oneness of Allah and the prophethood of

我们很高兴地宣布推出KaLM系列最新的Embedding模型： KaLM-embedding-multilingual-mini-instruct-v1.5 ，基于0.5B规模自回归模型，在 MTEB基准 上取得了领先的表现，欢迎大家试用并交流心得！ **多语种性能卓越**：中英能力出色（64.13 C-MTEB，64.94 MTEB），其他语种表现同 …