The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila Snail protein, and is also thought to be critical for mesoderm formation in the ...

2025年3月30日 · SNAI1 (Snail Family Transcriptional Repressor 1) is a Protein Coding gene. Diseases associated with SNAI1 include Cercarial Dermatitis and Adenomyosis. Among its related pathways are Cell junction organization and Regulation of …

Snail是近年发现的锌指转录因子，属于转录因子中的Snail超家族成员。 其第一次是在果蝇中被描述，Snail突变的果蝇胚胎表现为原肠胚缺陷，经证实与E-cadherin下调有关 [ 4 ] 。

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors.

2016年4月4日 · 效性的锌指蛋白转录因子Snail。 Snail 为Snail 家. 发现。 Snail 家族成员中包括Snail1（Snail）、Snail2. Snail 家族成员编. Snail 含有4 个锌指结构， 连接凹槽的氨基酸末端区域构成。 在人Snail 基. Snail 可与含. 这种转. 挥重要作用。 Ma 等. 达，但在非着床部位则没有检测到。 并且当胚胎. 表达。 但当用雌激素处理使胚胎着床后，在胚胎. 着床的基质周围同样检测到Snail 的高表达。 外，在假孕的小鼠子宫中也无Snail 的表达。 在胚. （1. 江汉大学 医学院病理学与 …

2021年1月19日 · It has been increasingly recognized that SNAIL1 and SNAIL2, as major EMT-inducers, might also be involved in drug resistance of cancer cells. We sought to determine a relation between SNAIL1/2, E-cadherin and N-cadherin expression, as well as ovarian cancer cells' resistance to cisplatin and EMT markers' level.

Increasing evidence indicates that methylation and acetylation of Snail1 also affects tumor metastasis. More importantly, Snail1 is involved in tumor immunosuppression by inducing chemokines and immunosuppressive cells into the tumor microenvironment (TME).

Snail (C15D3) Rabbit mAb detects endogenous levels of total Snail protein. Human, Mouse, Rat, Monkey. Monoclonal antibody is produced by immunizing animals with a recombinant human Snail protein. The epitope has been mapped to residues surrounding Asp36. Snail is a zinc-finger transcription factor that can repress E-cadherin transcription.

2016年6月15日 · The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.

2017年8月29日 · Snail基因家族是诱导上皮一问质细胞 转换的关键转录凶子。本文对上皮一问质细胞转换在生理和病理情况下的进展、Snail基因家族在上 皮一问质细胞转换过程中的作用及其与眼部纤维化疾病的关系作一综述。