High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer.

2022年1月5日 · Cell information for OVCAR-8. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Rapid tumor formation was observed for OVCAR3, OVCAR5 and OVCAR8, but only OVCAR8 reliably formed ascites. Tumors derived from OVCAR3, OVCAR4, and OVKATE displayed papillary features. Of the 11 lines examined, three (Kuramochi, SNU119 and UWB1.289) were non-tumorigenic.

We generated two HGSC cell lines with induced PTX resistance and P-gp overexpression suitable to test new and more effective P-gp inhibitors. Moreover, since OVCAR 8 has intrinsic Carboplatin resistance, our two OVCAR8 PTX R models are also apt to test the efficacy of drugs to revert platinum-taxane resistance.

2016年3月17日 · A 17 cisplatin resistance gene expression signature was associated with shorter survival across three independent datasets and distinguishes OVCAR-8R from OVCAR-8 cells. Genes up-regulated in OVCAR-8R spheroids are expressed higher in patients with shorter survival and vice-versa.

2023年12月27日 · We report the discovery and characterization of potent and selective small-molecule inhibitors of KIF18A motor activity and demonstrate promising activity toward CIN cancers.

2023年12月23日 · Transcriptome analysis of OVCAR-8 cells upon mRNA-based p53 reactivation revealed significant alterations in gene expression related to p53 signaling, such as apoptosis, cell cycle regulation, and DNA damage.

Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant cell line, NCI/ADR-RES, from human ovarian cancer cells. The parental cell line is OVCAR-8, obtained from a high-grade ovarian serous adenocarcinoma.

Cancer Cell Line: OVCAR-8. Aliases: OV:OVCAR-8, OVCAR-8, OVCAR8, CVCL_1629; Tissue: Ovary; Cellosaurus: CVCL_1629; OVCAR-8 is in CellMinerCDB, a searchable tool integrating cancer cell line pharmacogenomics data to link gene and drug activity signatures.

OVCAR-8细胞系是人类卵巢癌细胞系，来源于一位 64 岁的女性患有高度卵巢浆液性腺癌。 OVCAR8细胞系是NCI-60细胞系的一部分，广泛用于药物筛选和分子靶点的鉴定研究。 基因特征：OVCAR-8细胞可以通过慢病毒转染技术引入荧光素酶标记基因（LUC），这使得它们在生物成像和药物筛选研究中具有特殊价值。 分子特征：作为卵巢癌细胞系，OVCAR-8可能表达与卵巢 …