RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS
We have investigated the premise that abnormalities of TDP-43 in disease would be reflected by changes in processing of its target RNAs. To this end, we have firstly identified RNA targets of …
Nuclear RNA binding regulates TDP-43 nuclear ... - ScienceDirect
2022年7月19日 · RNA crosslinking and immunoprecipitation-sequencing (CLIP-seq) studies show that TDP-43 preferentially binds GU-rich RNA motifs, particularly in introns (Polymenidou et …
TDP-43 condensation properties specify its RNA-binding and …
2021年8月10日 · ChimeraRBP-CLIP shows that the CTD-mediated homomultimeric contacts recruit the chimeric protein close to the RNA-binding regions of endogenous TDP-43. Three …
Characterizing the RNA targets and position-dependent splicing ...
2011年2月27日 · Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG …
Characterizing TDP-43 interaction with its RNA targets - PMC
Several cross-linking and immunoprecipitation (CLIP) and RNA immunoprecipitation-sequencing (RIP-seq) analyses have indicated that TDP-43 in vivo can also specifically bind loosely …
Characterising the RNA targets and position-dependent splicing ...
Using individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP), we demonstrated that TDP-43 preferentially binds long clusters of UG-rich sequences in vivo. …
Distinct and shared functions of ALS-associated proteins TDP
2016年7月5日 · To identify in vivo RNA substrates recognized by TAF15, we performed CLIP (crosslinking immunoprecipitation)-seq in whole-brain tissue from adult mice using a …
TDP-43，登顶Cell 的新热点蛋白 - 知乎 - 知乎专栏
2020 年 10 月 3 日，墨尔本大学的 Seth L. Masters 教授团队发表题为 「TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS」 的研究成果， 阐释了 …
The cooperative binding of TDP-43 to GU-rich RNA repeats ... - eLife
2021年9月7日 · To understand through which molecular mechanisms TDP-43 targets pyrimidine-rich introns in cells as revealed by CLIP experiments, we considered whether a cooperative …
TDP‐43 regulates its mRNA levels through a negative feedback loop
TAR DNA‐binding protein (TDP‐43) is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) involved in RNA processing, whose abnormal cellular distribution …