We integrate spectroscopic optical coherence tomography (SOCT) with stimulated Raman scattering (SRS) to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine.

2023年10月27日 · Stimulated Raman scattering (SRS) microscopy has shown enormous potential in revealing molecular structures, dynamics, and couplings in complex systems. However, the sensitivity of SRS is fundamentally limited to the millimolar level due to shot noise and the small modulation depth.

2017年4月19日 · The method, termed SRS-SOCT, has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging, which would be valuable for many applications. We demonstrate the approach by imaging excised human adipose tissue and detecting the lipids’ Raman signatures in the high-wavenumber region.

2021年8月17日 · Swept-source optical coherence tomography (SS-OCT) is an imaging tool capable of providing three-dimensional information of biological tissues in vivo...

2023年4月26日 · 前段ss-oct和ss-octa已用于评估泪膜、结膜、角膜、房角（aca）、虹膜、晶状体、水平眼外肌和巩膜的结构和血管分布中。 360度眼前段显示，能更充分量化虹膜-小梁网接触（ITC）和周边虹膜粘连（PAS）水平，增加对房角的评估手段。

2024年6月19日 · Corresponding expansion and contraction of cellular layers can be imaged using optoretinography (ORG), based on phase-resolved optical coherence tomography (OCT). Until now, ORG could reliably...

Conclusions: The data indicate the potential of commercial OCT in measuring slow IOS in the outer retina suggesting that the rod SRS could serve as a biomarker for photoreceptor function. The presented approach could provide an easily implementable clinical tool for the early detection of diseases affecting photoreceptor health.

2019年8月19日 · Here, we introduce optical coherence refraction tomography (OCRT), which extends the superior axial resolution to the lateral dimension, synthesizing undistorted cross-sectional...

2018年1月25日 · In this review, we shall attempt to explain the physics behind swept source-optical coherence tomography (SS-OCT), the advantages and disadvantages of SS-OCT when compared with spectral domain-optical coherence tomography (SD-OCT), and the current clinical applications of SS-OCT.

2022年11月29日 · 扫频光学相干层析成像（Swept Source Optical Coherence Tomography, SS-OCT）则是其中的一种，它使用扫频光源来获取深度信息，具有高速度和宽频带的特点。 在SS-OCT系统中，光源的扫频信号（k-clock）是至关重要的...