2020年2月26日 · Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental disorders (NDDs), including...

2025年3月30日 · POGZ (Pogo Transposable Element Derived With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include White-Sutton Syndrome and Nail Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD1.

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2020年12月1日 · 今天阅读的文献是Pogz defciency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice，是实验室本周jc文章，今年11月7日在 nature communication 上发表的文章。 通讯作者有两位。 Sagiv Shifman和Yosef Yarom，二人均来自 耶路撒冷 希伯来大学，前者来自遗传系，目前的研究兴趣在自闭症的遗传学特点。 后者来自脑科学院，其目前研究兴趣在小脑的相关功能。 现在在以色列艾尔斯 …

Pogo transposable element with ZNF domain is a protein that in humans is encoded by the POGZ gene. [5] [6] The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system.

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该研究表明，在胚胎干细胞向神经命运分化的过程中，POGZ是维持ESC特性和上调神经基因表达的必要条件。 全基因组水平的结合分析表明，POGZ主要定位在基因启动子和增强子区域，其缺失会导致分化基因包括神经基因的失调。 在ESC 神经诱导 过程中，POGZ介导esBAF/BRG1的招募和H3K27ac信号对于神经祖细胞基因的正常表达至关重要。 菲沙基因承担了该研究中Flag-POGZ蛋白的CUT&Tag建库测序及部分数据分析工作。 研究材料： 小鼠胚胎干细 …

研究成果为POGZ突变导致的 神经系统发育障碍性疾病 提供了新的见解。 相关成果近日以Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF为题在线发表在Molecular Autism上。该研究工作得到国家重点研发项目的资助。 图1 POGZ缺失影 …

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