2024年12月1日 · Increased proportions of IFN-γ- and TNF-α-positive CD4 + T cells and CD8 + T cells in tumors were also detected in mice treated with LC3/Mut plus anti-PD-1 (Fig. 5 e-h and Fig. S8). These data suggest that combining LC3/Mut and anti-PD-1 treatment could effectively activate tumor-infiltrating CD4 + and CD8 + T cells in mice.

2019年10月30日 · We hypothesized that compounds that interact with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3) 1 and the disease-causing protein may target the latter...

LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究细胞自噬的活性和调控机制。 许多疾病，如癌症、神经退行性疾病和肝脏疾病等，与细胞自噬的异常相关，因此研究LC3蛋白及其参与的细胞自噬机制对理解这些疾病的发生和治疗具有重要意义。 LC3蛋白是一个亚家族，包含几个亚型或Isoform，包括LC3A、LC3B和LC3C。 这些亚型在结 …

在哺乳动物中，存在 4 种LC3异构体（LC3A、 LC3B 、 LC3B2和 LC3C），在不同的组织细胞中表达会有差异。 目前主要研究的是LC3A和LC3B，LC3C在许多细胞中表达量很低，研究的也较少。 其中每种异构体都可以有I和II两种亚型。 想要观察自噬有没有参与，最简单的就是做LC3的WB检测，它也是检测自噬必做的实验之一。 那么，在进行 LC3 检测实验之前时，需要了解哪些信息呢？ 首先， 需要知道样本的LC3表达量和表达的种类。 不表达或者表达量很低样本，就不 …

Low Complexity Communication Codec. This is an implementation of the the Bluetooth (r) LC3 Audio Codec revision 1.0 (released on 2020-09-15) targeting no_std environments. This is not currently approved or verified in any formal way other than my own testing against a codec that has been validated.

2024年5月17日 · Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme. As matter of fact, MMA patients manifest impairment of the primary metabolic network with profound damages that involve several cell components, many of which have not been discovered yet.

2018年8月1日 · This study evaluated whether lithium chloride (LiCl) prevents cytoplasmic accumulation of mutant-transforming growth factor β-induced protein (Mut-TGFBI) in granular corneal dystrophy (GCD) via activation of the autophagy pathway.

2023年1月1日 · Mechanistically, Lonp1 knockdown decreases area of mitochondrial networks and induces mitochondrial depolarization. Furthermore, Lonp1 inhibition reduces the level of LC3-II/I, PINK1 and Parkin, but promotes the level of p62.

异位表达fto-wt，但不是fto-mut，显着增加lc3-ii：i表达，lc3斑点显着增强,自噬体的数量提高。 这些结果证明FTO去甲基化的活性是前脂肪细胞中自噬所必需的。

2015年4月10日 · We first analysed the intracellular distribution of the microtubule-associated protein light chain 3 (LC3), which shifts from diffuse to punctate during autophagosome formation. 23 ESCs stably expressing either a GFP-LC3 wild-type fusion (LC3_wt) or a control GFP-LC3G120A mutant (LC3_mut) that fails to localise to autophagosomes 24 were ...