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迄今为止，人们发现此类抗体有13种，其中研究最为广泛、认识最深入的是抗Jo-1抗体，其阳性率也最高，为20%左右，因此，ASS常又称作抗Jo-1抗体综合征。

2017年9月16日 · 适用于定量测定人血清中抗Jo-1抗体 (Anti-Jo-1)的含量。

2024年7月20日 · Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.

Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.(4,5).

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Jo-1 Antibody - Jo-1 Antibody occurs most frequently (31%) in patients with polymyositis, but has also been found in patients with dermatomyositis, and the polymyositis/scleroderma "overlap syndrome" (PM/SCL) or polymyositis/systemic lupus …

'Jo-1 Antibody' refers to an autoantibody that is associated with inflammatory myositis. It is triggered by tissue injury and inflammation in the lung, particularly in response to harmful environmental factors like air pollution and smoking.

Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as ...

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