Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。 Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。 Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50 =1.13 μM)。 * Please select Quantity before adding items. • Nat Nanotechnol. 2024 Oct 28. [Abstract] • Nature. 2023 Jun;618 (7966):799-807. [Abstract] • Nature. 2022 …

2023年2月1日 · Chloroquine (Aralen, CHQ, CQ)，又称氯喹，是氨基喹啉类的抗疟药和和抗阿米巴药，也是自噬溶酶体抑制剂。 氯喹不能直接杀死疟原虫，通过与核蛋白结合，插入到DNA的双股螺旋之间，从而阻止DNA复制与RNA转录，进而抑制疟原虫繁殖。 氯喹还能通过提高溶酶体中pH升高使溶酶体中酸性水解酶失活，从而抑制细胞内自噬溶酶体的融合与降解。 产品性质. CAS号 (CAS NO.) 运输和保存方法. 冰袋运输。 粉末直接保存于 -20℃，有效期 3 年。 建议分装后 …

2018年2月28日 · Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show...

2023年3月9日 · A series of autophagy-targeted antimetastatic clioquinol (CLQ) platinum(IV) conjugates were designed and prepared by incorporating an autophagy activator CLQ into the platinum(IV) system. Complex <b>5</b> with the cisplatin core bearing dual CLQ ligands with potent antitumor properties was screened …

1996年1月1日 · This chapter provides isolation and methods of detection of Clq autoantibodies. Clq exists in the form of Cl, a calcium-dependent complex with two molecules each of the Cl esterases, Clr, and Cls that bind to the collagen-like region (CLR) of one molecule of Clq.

2024年12月10日 · EF-FeS 2-CF was found to achieve 92.4 ± 0.1% removal of 5 mg/L CLQ after 30 min at 20 mA and exhibited an outstanding catalytic performance for CLQ removal in wide ranges of operating conditions, excellent recyclability with low iron leaching (>90% 30-min CLQ removal efficiency for all five cyclic experiments which led to only an accumulative ...

2022年5月9日 · 氯喹 (clq) 和羟氯喹 (hclq) 是几十年来主要用于治疗各种人类疾病的化合物。 然而，关于它们的作用机制的一些内在细节，特别是在分子水平上，仍然未知或在文献中提出了有争议的结果。

2024年12月4日 · CLq测定偏低，通常指的是血液中补体C1q的成分含量低于正常值。 补体C1q是构成补体C1的一个重要成分，在免疫反应中扮演着重要角色，特别是在经典途径激活补体时，C1q的参与至关重要。

CLQ (Cut, Cleaned, and Quartered) Expertly prepared for convenience, our CLQ cuts ensure ease of cooking without compromising on quality. Sourced from trusted suppliers, these portions maintain freshness and taste for a hassle-free culinary experience.

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