The Link Reaction involves the transfer of electrons from NADH and FADH2 to the electron transport chain, which is made up of a series of electron carriers. This transfer of electrons creates a proton gradient across the inner mitochondrial membrane, producing ATP through the process of oxidative phosphorylation.

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The first stage of aerobic respiration is the link reaction, which transports pyruvate into the mitochondria. As glycolysis splits glucose into two pyruvate molecules, the link reaction occurs twice per molecule of glucose.

The Link reaction, also known as pyruvate decarboxylation forms an important link between the metabolic pathways of glycolysis and the citric acid or Krebs cycle. In eukaryotes, the reaction takes place only inside the mitochondrial matrix; in prokaryotes similar reactions take place in the cytoplasm and at the plasma membrane. [1] To summarize:

The link reaction begins with pyruvic acid (letter “A”) diffusing into the mitochondrial matrix through the mitochondrial membrane (“B”). As pyruvate enters, enzymes snip off its carboxyl group (which you can see on the left side of the structural formula of pyruvate: it’s the carbon that’s double-bonded to one oxygen, and then ...

2025年2月13日 · pyruvate + NAD + CoA → acetyl CoA + carbon dioxide + reduced NAD. The link reaction occurs in the mitochondrial matrix. It dehydrogenates and decarboxylates the three-carbon pyruvate to produce the two-carbon acetyl CoA that can enter the Krebs cycle.

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