P66Shc, a key regulator of metabolism and mitochondrial ROS ... - PubMed
Changes to p66Shc expression in mouse blastocysts were measured using quantitative RT-PCR, immunoblotting and immunofluorescence followed by confocal microscopy. Changes to …
人类 p66Shc 基因新型抗氧化功能和亚型特异性 ... - X-MOL
2014年5月7日 · p66Shc 被证明是一种负性寿命调节剂，它在线粒体中充当促氧化蛋白；然而，p66Shc 表达和功能的调控机制尚不完全清楚。 这项研究为 p66Shc 作为抗氧化剂和细胞分化 …
p66Shc signaling and autophagy impact on C2C12 myoblast
2024年3月8日 · Growing evidence suggests that p66Shc activation is involved in deleterious processes and is critical in aging-related cellular alterations. However, the role of p66Shc and …
Distribution of the p66Shc Adaptor Protein Among Mitochondrial …
2024年11月29日 · p66Shc is an adaptor protein and one of the cellular fate regulators since it modulates mitogenic signaling pathways, mitochondrial function, and reactive oxygen species …
p66Shc in Cardiovascular Pathology - PMC
p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc’s …
High glucose-induced p66Shc mitochondrial translocation …
2024年4月20日 · High glucose induces the expression and mitochondrial translocation of p66Shc, which promotes MAMs formation and stimulates PINK1-PRKN-mediated mitophagy. …
The Role of p66shc in Oxidative Stress and Apoptosis - PMC
p66shc is a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Mice knocked out for p66shc have a lifespan ~ 30% longer and …
p66Shc activation promotes increased oxidative phosphorylation and ...
2018年11月20日 · Our findings indicate that expression and activation of p66Shc renders CNS cells more sensitive to Aβ toxicity by promoting mitochondrial OXPHOS and ROS production …
P66Shc, a key regulator of metabolism and mitochondrial ROS …
Do high oxygen tension and high glucose concentrations dysregulate p66Shc (Src homologous-collagen homologue adaptor protein) expression during mouse preimplantation embryo …
The p66shc adaptor protein controls oxidative stress response …
1999年11月18日 · Here we report that targeted mutation of the mouse p66shc gene induces stress resistance and prolongs life span. p66shc is a splice variant of p52shc/p46shc (ref. 2), a …