mTOR 是一种丝氨酸/苏氨酸激酶，属于 PI3K 相关激酶 (PIKK) 家族的成员，可与几种蛋白质相互作用形成两个不同的复合物，分别称为 mTOR 复合物 1 (mTORC1) 和 2 (mTORC2)。 mTORC1 包含 mTOR、Raptor、PRAS40、mLST8 和 DEPTOR，对 雷帕霉素 (Rapamycin) 敏感；mTORC2 包含 mTOR、Rictor、SIN1、Protor- 1、mLST8 和 DEPTOR，对雷帕霉素急性治疗不 …

2011年10月7日 · The signaling adaptor p62 is a critical mediator of important cellular functions, owing to its ability to establish interactions with various signaling intermediaries. Here, we identify raptor as an interacting partner of p62. Thus, p62 is an integral part of the mTORC1 complex and is necessary to m …

值得一提的是，本人课题组与清华大学的俞立老师课题组发现要被自噬降解的蛋白上的标记的多泛素链与选择性自噬受体蛋白p62，通过液-液分离相变形成p62 body而被自噬体降解（Cell Research 2018）【9】。

p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key pathways that regulate tissue homeostasis, inflammation, and several common diseases including cancer.

2013年8月8日 · The signaling adaptor p62 binds raptor, and integral component of the mTORC1 pathway. p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required for mTORC1 translocation to the lysosome and its subsequent activation. Here we show that TRAF6 is recruited to and activates mTORC1 through p62 in amino acid-stimulated cells.

2021年6月22日 · The transcription factor Nrf2 regulates expression of a bundle of ROS detoxifying genes. p62 activates Nrf2 by interaction with and autophagosomal degradation of the Nrf2 inhibitor Keap1. Moreover, p62 activates mTOR, the central kinase of the mTORC1 sensor complex that controls cell proliferation and differentiation.

2023年9月4日 · 雷帕霉素靶点 （The target of rapamycin，TOR）对于大部分学者而言都不陌生，它是一种高度保守的丝氨酸/苏氨酸蛋白激酶，在调节细胞生长、新陈代谢过程中具有核心作用。 哺乳动物TOR（mTOR）作为代谢研究中的持续热点，其在机体中的调节作用、生理作用已得到广泛的研究。 今天要给大家介绍一篇关于mTOR的综述，题为The central moTOR of metabolism。 这篇综述讨论了有关 mTOR 信号传导调节和 mTOR 对碳水化合物、核酸、脂质和蛋白质代谢 …

本研究拟首先从细胞水平、动物模型、临床样品三方面揭示mTOR具有调控P62降解的作用以及P62蛋白水平与自噬及凋亡的关系，研究mTOR与P62在胶质瘤中存在相互作用和降解p62的分子机制。

In this study, we found that p62 may be used as a biomarker for assessing mTOR-dependent autophagy defects and is indicated for combination therapy with mTOR inhibitors in appropriate patients. In summary, by integrating omics analysis and the newly developed BRCA1/ 2 WT HGSC mouse model, we found that elevated p62 expression might be a ...

值得一提的是，本人课题组与清华大学的俞立老师课题组发现要被自噬降解的蛋白上的标记的多泛素链与选择性自噬受体蛋白p62，通过液-液分离相变形成p62 body而被自噬体降解（Cell Research 2018）。