2021年8月10日 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid …

mRNA–LNP therapy is an innovative nucleic acid therapy method that uses lipid nanoparticles as carriers to deliver mRNA into cells, enabling the regulation of specific genes.

2024年12月13日 · An in vitro whole blood assay was developed to assess the impact of mRNA-LNPs on immune cell function, cytokine release, and complement activation. mRNA-LNPs …

2024年12月1日 · Lipid nanoparticles (LNPs) used for nonviral gene delivery have achieved significant success, particularly in COVID-19 mRNA vaccines. LNPs are routinely …

2 天之前 · Lipid nanoparticle (LNP)-based mRNA delivery has a lot of potential in combating a wide range of diseases, but delivering mRNA to specific cell types continues to be challenging. …

Additionally, it explores the potential of LNP-mediated mRNA delivery as a therapeutic strategy for these diseases. Various approaches to overcoming BBB-related challenges and enhancing …

2 天之前 · The smaller-sized mRNA of the truncated version offers the advantage of better efficacy at lower doses. “We are pushing the frontier of mRNA therapy for cancer with our …

2025年1月15日 · In this study, we have compared the difference between two SARS-CoV-2 receptor-binding domain (RBD) mRNA-Lipid nanoparticle (LNP) vaccines prepared from two …

Significance Effective delivery strategies are vital for message RNA (mRNA) vaccines and therapeutics, with lipid nanoparticles (LNPs) being forefront. Developing ionizable lipids, a key …

2022年9月23日 · Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs, …