Metabotropic glutamate receptor 5 is an excitatory G q -coupled G protein-coupled receptor [5] predominantly expressed on the postsynaptic sites of neurons. [6] In humans, it is encoded by …

2023年1月16日 · Here we show that mGluR5 is dynamically organized in perisynaptic nanodomains that localize close to, but not in the synapse. The C-terminal domain of mGluR5 …

2022年9月20日 · The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain.

Metabotropic glutamate receptor 5 (mGluR5) is a member of the G protein-coupled receptor (GPCR) superfamily and when activated by glutamate couples to the heterotrimeric G protein …

The mGluRs in group I, including mGluR 1 and mGluR 5, are stimulated most strongly by the excitatory amino acid analog L-quisqualic acid. [4][16] Stimulating the receptors causes the …

2024年1月12日 · Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic …

The metabotropic glutamatergic receptor subtype 5 (mGluR5) may represent a promising therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 findings …

2024年1月12日 · Background: Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and …

2016年2月3日 · Spinal mGluR5 is a key mediator of neuroplasticity underlying persistent pain. Although brain mGluR5 is localized on cell surface and intracellular membranes, neither the …

We summarize and deliver comparative analyses of mGluR5-specific PET radiotracers and their applications in understanding the pathophysiology of mGluR5-related nervous system …