Recombinant Human N-Glycosylase/OGG1 是一种DNA修复酶，其作为一种修饰酶, 主要具有DNA糖基化酶活性和脱嘌呤/脱嘧啶（apurinic/apyrimidinic，AP）裂解酶活性两种活性。 N-糖基化酶活性能从双链DNA 上去除受损嘌呤碱基产生脱嘌呤 (AP) 位点，而 AP 裂解酶活性则能从 AP 位点的 3 处进行切割产生一个 5 磷酸和一个 3 磷酸-α，β-不饱和醛。 此外OGG1还能切割其它异常碱基对，比如与胞嘧啶配对的7,8-二羟基-8-氧代鸟嘌呤 (8-氧代鸟嘌呤), 与胞嘧啶配对的8-羟基 …

The codon 326 polymorphism in the hOGG1 gene has been suggested to reduce DNA repair enzyme activity based on in vitro functional analysis. The goal of the present study is to determine whether the codon 326 polymorphism was significantly associated with alterations in individual risk for lung cancer.

8-羟基鸟嘌呤DNA糖苷酶 （hOGG1）是一种DNA糖基化酶，由 OGG1基因 编码。 它是负责切除 8-氧代鸟嘌呤 （8-oxoG）的主要酶，8-氧代鸟嘌呤是暴露于活性氧（ROS）而产生的诱变碱基副产物。 OGG1是一种双功能的糖基化酶，因为它既能裂解诱变病变的糖苷键，又能导致DNA骨架上的断链。 该基因C端区域的 替代剪接 将剪接变体分为两大类，1型和2型，取决于序列的最后一个外显子。 1型替代剪接变体以第7外显子为终点，2型以第8外显子为终点。 8-羟基鸟嘌呤DNA …

The human 8-oxoguanine DNA glycosylase (hOGG1) protein is responsible for initiating base excision DNA repair of the endogenous mutagen 8-oxoguanine.

sylase,hOGG1)是人体内能特异识别8鄄oxoG 并将其切除修复的酶。hOGG1的修复效率降低和功能缺失是造成辐射或化学致突变而诱发相关癌症的重要因素,hOGG1的寡核苷酸多态性(sing. le nucleotide polymorphism,SNP)造成了癌症遗传易感性人群的不同。本文通过基因结构和功能、生物信号传导通路、�. 因yOGG1,1997 年,同源序列的人源OGG1 基因,并命名为hOGG1基因。hOGG1 基因位于人染色体3p26.2区域,根据最后一个外显子序列的不�. 分为两个亚型,亚型1包 …

The codon 326 polymorphism in the hOGG1 gene has been suggested to reduce DNA repair enzyme activity based on in vitro functional analysis. The goal of the present study is to determine whether the codon 326 polymorphism was significantly associated with alterations in individual risk for lung cancer.

2005年7月29日 · The human homologue of the yeast DNA repair enzyme, 8-oxoguanine-DNA glycosylase (hOGG1), excises 8-oxoguanine, an oxidative form of the guanine nucleotide. 1 HOGG1 shares a 38% identity with...

2018年1月24日 · Human 8-oxoguanine DNA glycosylase (hOGG1) plays a significant role in maintaining the genomic integrity of living organisms for its capability of repairing DNA lesions. Accurate detection of hOGG1 activity would greatly facilitate the screening and early diagnosis of …

1997年9月1日 · Results: Here, we report the identification of the active-site amine of the human 8-oxoguanine DNA glycosylase (hOgg1), a human BER superfamily protein that repairs the mutagenic 8-oxoguanine lesion in DNA.

hogg1是一种dna修复酶，可以从dna切除修复8-羟基鸟嘌呤。 研究表明该基因变异可能会影响个体修复损伤DNA的能力，促进肺癌的发生。 我们前期工作证实hOGG1基因甲基化与非小细胞肺癌 (NSCLC) 相关 (Lung Cancer,2008; J Thorac Oncol,2010)，进一步实验得出hOGG1基因甲基化异 …