2024年12月24日 · EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Diseases associated with EIF5 include Fibroosseous Pseudotumor Of Digits and Mehmo …

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S …

We recently showed in a publication in Nature that the eukaryotic translation initiation factor eIF5 has a second regulatory function and is a GDI (GDP dissociation inhibitor) in addition to its …

2014年9月2日 · eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA iMet ternary complex with a critical role in initiation codon selection. Previous work suggested that …

The translation factor eIF5 is an important partner of eIF2, directly modulating its function in several critical steps. First, eIF5 binds eIF2/GTP/Met-tRNA(i)(Met) ternary complex (TC), …

During translation initiation in eukaryotes, initiation factor eIF5 is required for hydrolysis of GTP bound to eIF2 (the protein which brings the initiator Met-tRNA i to the 40S subunit). Here we …

2017年4月20日 · Using a combination of ribosome profiling and in vitro biochemistry, we report a much broader role for eIF5A in elongation and uncover a critical function for eIF5A in …

2010年9月1日 · First the eIF5-CTD provides for binding between eIF5 and eIF2•GDP, which physically antagonises eIF2B (GEF) binding. Our genetic data suggest that this is most critical …

2018年11月26日 · The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.

2003年1月10日 · When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed: 11166181). Start codon recognition also induces a …