Epidermal growth factor receptor (EGFR) and its ligands are frequently upregulated in human cancers. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion, and metastasis. Specific abrogation of EGFR results in cell cycle arrest, apoptosis, or dedifferentiaton of cancer cells.

RTK plays most important roles in cell cycle regulation. RTKs are classified into 20 families. The most studied RTKs in terms of cell cycle include epidermal growth factor (EGF) receptor (EGFR) family, insulin receptor family, platelet-derived growth factor (PDGF) receptor (PDGFR) family, and nerve growth factor (NGF) receptor (NGFR).

2022年7月13日 · Learn about eGFR, how your kidneys filter waste, and why early detection of CKD is crucial for protecting kidney health. Your kidneys filter your blood by removing waste and extra water to make urine. The glomerular filtration …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated ...

2023年9月13日 · 对于中青年成年人，推荐使用CKD-EPI公式来估算肾小球滤过率（eGFR），其中用基于 血清肌酐 和 胱抑素C 的CKD-EPI Scr-SCysC联合公式估算最准确¹。 就是下图的第三个公式，可以用科学计算器带入血清肌酐和胱抑素C值（注意单位）手动计算出来。 对于老年人的肾小球滤过率估算公式，目前有争议，但是最新的老年人慢性肾病诊治中国专家共识仍然推荐CKD-EPI公式²，并且认为基于血清肌酐和胱抑素C的CKD-EPI Scr-SCysC联合公式估算eGFR更加 …

2022年12月1日 · Here we review the mechanisms by which EGFR regulates cell metabolism, including by modulation of gene expression and protein function leading to control of glucose uptake, glycolysis, biosynthetic pathways branching from glucose metabolism, amino acid metabolism, lipogenesis, and mitochondrial function.

2016年7月4日 · In this Review we focus on the role of the EGFR signalling pathway in the kidney under physiological conditions and during the pathophysiology of chronic kidney diseases and explore the clinical...

We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous pyrimidines partially rescues the impairment in cell growth. Finally, we show that high expression of CPS1 in lung adenocarcinomas correlated with worse patient prognosis in publicly available databases.

2021年6月17日 · There are five stages: Stage 1 (eGFR of 90 or higher) indicates mild kidney damage, but your kidneys are working well. Stage 2 (eGFR between 60 and 89) indicates an increase in kidney damage from stage 1, but the kidneys continue to function well. Stage 3 (eGFR between 30 and 59) means you have decreased kidney function and may experience symptoms.

Progression through the cell cycle causes changes in the cell's signaling pathways that can alter EGFR signal transduction. Here, we describe drug-derived protocols to synchronize HeLa cells in various phases of the cell cycle, including G1 phase, S …