AKT Facilitates EGFR Trafficking and Degradation by ... - Science
We show that the AKT inhibitor–induced increase in ERK activation requires active EGFR, consistent with AKT facilitating EGFR degradation as a mechanism to reduce ERK signaling. …
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
The PI3K-AKT-mTOR signaling cascade controls metabolism, proliferation, cell size, survival and motility. In cancer, this pathway is often hyper-activated due to activating mutations to EGFR …
干货：九大肿瘤相关信号通路介绍-EGFR通路及靶标介绍（一）
肿瘤表皮生长因子受体(EGFR)是一个170KDa的跨膜糖蛋白受体酪氨酸激酶，由表皮生长因子激活，影响细胞的生长和分化。 EGFR 家族又称为EGFR酪氨酸激酶家族，由4个不同的受体酪氨 …
EGF‑stimulated AKT activation is mediated by EGFR recycling via …
Collectively, we suggest that EGF-stimulated recycling of EGFR to the plasma membrane induces downstream signaling leading to AKT phosphorylation. Suppression of EGFR membrane …
Regulation of EGF-stimulated activation of the PI-3K/AKT
2022年11月29日 · The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously …
Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung ...
2021年2月10日 · Our gene chip array, quantitative polymerase chain reaction validation, and shRNA-based high-content screening identified the Akt kinase lanthionine synthetase C-like …
Convergent Akt activation drives acquired EGFR inhibitor ... - Nature
2017年9月4日 · Our findings provide a new rationale to test combined Akt plus EGFR inhibitor treatment, specifically in EGFR-mutant NSCLCs with high pAkt levels, to overcome acquired …
An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted …
4 天之前 · Akt activity is shown in (D). β-actin served as the loading control for panel D. The mean Agrin protein normalized to EGFR +/− SD and pAkt/Akt ratio are shown (n = 3, Students’ t test, …
FDX1 Regulates the Phosphorylation of ATM, DNA-PKcs Akt, and EGFR …
14 小时之前 · EGFR and Akt are known contributors to radioresistance and cell survival [15,16,17]. Phosphorylation of EGFR at tyrosine 845 (Y845), an activation site for EGFR, was …
经典信号通路总结——PI3K/AKT/mTOR信号通路 - 知乎
2022年8月1日 · 当它与生长因子受体（如EGFR）结合后，可改变Akt的蛋白结构并使其活化，并以磷酸化作用激活或抑制下游一系列底物如凋亡相关蛋白Bad、Caspase9活性，从而调节细胞 …